ArticlePloS one2025
Red cell distribution width (RDW) is independently associated with all-cause mortality in adult patients with osteomyelitis admitted to the intensive care unit.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Sarcopenia and inflammatory markers in early-stage breast cancer: a retrospective case-control study of NLR, MLR, RDW-CV, and HRR in middle-aged and elderly women.Frontiers in surgery · 2026Article
- Association between the red cell distribution Width - coefficient of variation with colon cancer and all-cause mortality: insights from the 1999-2018 NHANES.BMC gastroenterology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
objectiveThis study aims to investigate the correlation between red cell distribution width (RDW) and overall mortality in adults diagnosed with osteomyelitis.
methodsIn this retrospective study, we examined data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, comprising 2,700 patients with osteomyelitis and available RDW data on the initial day of admission. Employing Kaplan-Meier survival analysis, we assessed the incidence rate of primary outcome events among groups categorized by RDW levels (Q1: RDW ≤ 13.5, Q2: 13.5 < RDW ≤ 14.6, Q3: 14.6 < RDW ≤ 16.1, Q4: 16.1 < RDW), with differences evaluated using the Log-rank test. Subsequently, Cox proportional hazards analyses were conducted to investigate the correlation between RDW and the overall mortality risk. Additionally, we performed stratified analyses based on factors such as gender, congestive heart failure, diabetes, and myocardial infarction to scrutinize the consistency of RDW's prognostic significance.
resultsOver the 90-day follow-up, 10.7% of patients with osteomyelitis succumbed. Unadjusted RDW correlated significantly with in-hospital, 30-day, and 90-day mortality (p < 0.05). Higher RDW levels proved more effective in predicting increased risks. RDW emerged as an independent prognostic indicator, showing no significant interactions with sex, congestive heart failure, diabetes, and myocardial infarction (interaction p-values: 0.254 to 0.920).
conclusionsThe noteworthy link between RDW and heightened all-cause mortality in patients with osteomyelitis who were hospitalized in the intensive care unit highlights RDW's potential as a valuable marker for identifying at-risk individuals during hospitalization.
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