Evidence map›Paper›PMID 40956776›Full record

ArticleBlood purification2026

Hemolysis Monitoring Practices during Extracorporeal Membrane Oxygenation: A Survey Report.

Amy E Strong, Kristina Rudolph, Michelle R Denburg, Aditya Badheka

Abstract read
In one paragraph

Article in Blood purification, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy E StrongDivision of Nephrology, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA, amy-strong@uiowa.edu.
Kristina RudolphUniversity of Iowa ECMO Program, Iowa City, Iowa, USA.
Michelle R DenburgChildren's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
Aditya BadhekaUniversity of Iowa ECMO Program, Iowa City, Iowa, USA.

Funding

Mentoring of Early Career Researchers from Diverse BackgroundsK26DK138375 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Michelle Denburg · 2023 to 2026
$424k
NIDDK NIH HHS K26 DK138375
6 · The paper itself

Abstract

introductionIntravascular hemolysis is a significant complication of extracorporeal membrane oxygenation (ECMO), associated with adverse outcomes such as kidney failure and increased mortality. There is wide variability in the cited incidence of this complication. This survey study aimed to characterize the variability in hemolysis monitoring practices across ECMO centers.

methodsThe survey, distributed via the Extracorporeal Life Support Organization (ELSO) newsletter, received 26 responses from various healthcare professionals, including nurses, perfusionists, respiratory therapists, and physicians. Respondents represented both pediatric and adult ECMO units, primarily from academic centers in the USA (46%).

resultsFindings revealed that 92% of these centers use centrifugal pumps, with heparin and bivalirudin being the preferred anticoagulants. While 68% of respondents reported having a standard protocol for hemolysis monitoring, the specific protocols varied widely. Plasma-free hemoglobin was the most commonly monitored laboratory test. Definitions for what were considered significant hemolysis varied as well and were primarily identified by red urine and elevated plasma hemoglobin levels. Interventions to address hemolysis included adjusting pump speed, repositioning cannulas, replacing pump heads or oxygenators, and performing plasmapheresis.

conclusionThe study highlights the variability in hemolysis monitoring practices among ECMO centers. Further research is warranted to establish optimal monitoring protocols to detect and potentially treat the complication of hemolysis.

Indexed as

Extracorporeal Membrane OxygenationHemolysisAdultAnticoagulantsHemoglobinsHeparinHirudinsHumansMonitoring, PhysiologicPeptide FragmentsRecombinant ProteinsSurveys and QuestionnairesAnticoagulantsbivalirudinHemoglobinsHeparinHirudinsPeptide FragmentsRecombinant ProteinsAKIExtracorporeal membrane oxygenationHemolysisPlasma hemoglobinSurvey study

Identifiers

PMID40956776
PMCPMC13100939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.