ArticleKidney3602026
Thickening of Glomerular Basement Membrane Is Associated with Long-Term Prognosis in Patients with IgA Nephropathy.
Article in Kidney360, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
key pointsIgA nephropathy (IgAN) patients with thickening of glomerular basement membrane had a higher risk of progressing to ESKD independent of international risk-prediction tool in IgAN. Thickening of glomerular basement membrane in IgAN patients was positively correlated with mesangial hyperplasia.
backgroundGlomerular basement membrane (GBM) ultrastructural abnormalities are common in IgA nephropathy (IgAN); however, few studies have focused on clinical significance and prognostic value of GBM ultrastructural changes in IgAN patients.
methodsA retrospective longitudinal cohort with 1006 biopsy-proven primary IgAN patients was collated. GBM thickness and texture of each case were assessed under transmission electron microscope. The primary end point was ESKD. Cox proportional hazards regression model was built to determine risk factors. Immunofluorescent staining was performed on patient kidney biopsy samples to validate the correlation between mesangial proliferation and abnormal GBM thickness. Twenty single nucleotide polymorphisms independently associated with IgAN in previous genome-wide association studies were genotyped in 617 patients, and whole exome sequencing was performed in 56 patients to investigate potential variants underlying GBM ultrastructural changes.
resultsOf 1006 patients, 52% were female, and the mean age was 37.3±12.3 years old. Among all patients, 80 (8%) had abnormal thickness of GBM including 29 (3%) thickening of GBM and 51 (5%) thinning of GBM. Abnormal GBM texture was found in 25 (2%) patients. During a mean follow-up time of 46.4 months, 91 (9%) patients progressed to ESKD. By Cox regression analyses, we demonstrated that thickening of GBM at biopsy increased the risk of ESKD before (hazard ratio [HR], 3.64; 95% confidence interval [CI], 1.47 to 7.55) and after adjusted by Oxford Scoring (HR, 2.92; 95% CI, 1.12 to 6.48) or international risk-prediction tool in IgAN (HR, 3.51; 95% CI, 1.41 to 7.29). Relevance analyses showed that GBM thickening was positively correlated with mesangial hyperplasia and proliferation, but not genetic variants in IgAN patients.
conclusionsThickening of GBM correlated with mesangial hyperplasia and proliferation was associated with ESKD in IgAN patients, demonstrating the potential of incorporating ultrastructural changes into the pathologic evaluation system of IgAN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.