ArticleMicrobiology (Reading, England)2025
The interaction between IL-17 and gut microbiota contributes to cholestatic liver disease in children.
Article in Microbiology (Reading, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities.Pharmacological reviews · 2026Review
- Therapeutic modulation of the gut microbiota by traditional Chinese medicine in the management of cholestatic liver injury.Frontiers in cellular and infection microbiology · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
The pathogenesis of cholestatic liver disease (CLD) is unknown, but the influence of gut microbiota and inflammation cannot be ignored. In this study, we attempted to provide theoretical insights for the diagnosis and treatment of CLD in children by analysing the association between gut microbiota, IL-17 levels and clinical characteristics. This research involved 21 children diagnosed with CLD and 11 healthy controls. Blood and faecal samples were collected from these participants. Blood samples underwent analysis for clinical indicators and IL-17 concentrations. Gut microbiota was examined through 16S rRNA gene sequencing for identification and functional prediction. A positive correlation between IL-17 levels and clinical parameters (total bile acids, alanine aminotransferase, aspartate aminotransferase and triglycerides) in children with CLD was observed. Notably, children with CLD exhibited reduced diversity and disturbances in gut microbiota, highlighted by a severe decrease of
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