Evidence map›Paper›PMID 40956465›Full record

ReviewCurrent allergy and asthma reports2025

Lymphoproliferative Disorders Mimicking Rheumatologic Disease: A Clinical Reasoning Perspective.

Jeffrey Z Shen, Eric D Carlsen, Luis F Carrillo, Dahima Cintron, Ben Kellogg, Jamie Lim, Matilda Nicholas, Elijah Lackey, John Dasher

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeffrey Z ShenDuke Department of Medicine, Division of Rheumatology and Immunology, NC, Durham, USA. jzs4@duke.edu.
Eric D CarlsenDuke Department of Pathology, Division of Hematopathology, NC, Durham, USA.
Luis F CarrilloDuke Department of Pathology, Division of Hematopathology, NC, Durham, USA.
Dahima CintronDuke Department of Medicine and Pediatrics, Division of Rheumatology, NC, Durham, USA.
Ben KelloggDuke Department of Medicine, Division of Rheumatology and Immunology, NC, Durham, USA.
Jamie LimDuke Department of Medicine, Division of Rheumatology and Immunology, NC, Durham, USA.
Matilda NicholasDuke Department of Medicine, Division of Rheumatology and Immunology, NC, Durham, USA.
Elijah LackeyDuke Department of Medicine, Division of Rheumatology and Immunology, NC, Durham, USA.
John DasherBirmingham Department of Medicine, Division of Hematology and Oncology, University of Alabama, AL, Tuscaloosa, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewLymphoproliferative disorders encompass a variety of hematologic diseases that are increasingly recognized. Patients with these conditions may present to rheumatologists or other specialists prior to a hematologist-oncologist. This review is intended to highlight key distinguishing features between rheumatologic conditions and lymphoproliferative disorders, and suggest diagnostic approaches. RECENT

findingsRecent studies have shown that lymphoproliferative diseases can mimic rheumatologic disease, and differentiation is complex. Advances in imaging techniques such as FDG PET/CT, and improved understanding of lymph node histopathology have improved diagnostic accuracy. Attention to specific details such as the pattern of organ involvement, the presence or absence of key clinical features, and the consistency of treatment response can assist in accurate diagnosis. Our review highlights the importance of considering lymphoproliferative disorders in the differential diagnosis of rheumatologic disease. A thorough clinical history, targeted biopsies, and collaboration with hematopathologists are essential for timely diagnosis and care. Future research should concentrate on identifying biomarkers and formulating diagnostic algorithms to aid in differentiating lymphoproliferative disorders from autoimmune diseases, which will ultimately improve patient outcomes.

Indexed as

Lymphoproliferative DisordersRheumatic DiseasesClinical ReasoningDiagnosis, DifferentialHumansPositron Emission Tomography Computed TomographyDiagnosisLupusLymphadenopathyLymphomaMimics

Identifiers

PMID40956465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.