Exploration of Novel Pyrazole Derivatives: Design, Synthesis, and Integrated Biological Profiling (In Vitro and In Silico) of Their Antioxidant, Antibacterial, and Antimitotic Properties.

Muneera S M Al-Saleem, Yousef E Mukhrish, Bharath Kumar Chagaleti, Jehan Y Al-Humaidi, Kathiravan Mk, Ali Oubella, Reda A Haggam

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Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Muneera S M Al-SaleemDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh , 11671, Saudi Arabia.

Yousef E MukhrishDepartment of Physical Sciences, Chemistry Division, College of Science, Jazan University, P.O. Box. 114, 45142, Jazan, Saudi Arabia.

Bharath Kumar ChagaletiDepartment of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India. bharathkumarchagaleti@gmail.com.

Jehan Y Al-HumaidiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh , 11671, Saudi Arabia.

Kathiravan MkDr A. P. J. Abdul Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India.

Ali OubellaLaboratory of Organic & Physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.

Reda A HaggamDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia. relhaggan@iu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the biological activities of synthetic derivatives 7a-b, focusing on antioxidant, antibacterial, antimitotic, and mitotic index assays after NMR and mass spectrometry characterization. Derivative 7b showed superior antioxidant activity, with 75.19 ± 0.11% inhibition at 2.5 µmol/mL and an IC

Indexed as

Anti-Bacterial AgentsAntimitotic AgentsAntioxidantsDrug DesignPyrazolesGram-Negative BacteriaHumansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsAntimitotic AgentsAntioxidantsPyrazolesAntibacterialAntimitoticAntioxidantIn-silicoIn-vitroPyrazole

Identifiers

PMID40956462

DOI10.1007/s10895-025-04555-w

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.