Evidence map›Paper›PMID 40956407›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Early astrocyte-targeted intervention guided by

Shenrui Guo, Feng Wei, Yuge Chang, Shuqi Wu, Zhiyin Lou, Yufei Ma, Qi Huang, Kun He, Chenglai Fu, Xianyi Cao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shenrui GuoDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Feng WeiDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuge ChangDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuqi WuDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhiyin LouDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yufei MaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi HuangPET Center, Huashan Hospital, Fudan University, Shanghai, China.
Kun HePET Center, Huashan Hospital, Fudan University, Shanghai, China.
Chenglai FuInstitute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xianyi CaoDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Sheng LiangDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiwei ChengDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yafu YinDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yinyf-2001@163.com.ORCID 0000-0002-4818-6655

Funding

National Natural Science Foundation of China 81974270National Natural Science Foundation of China 82472014Natural Science Foundation of Shanghai Municipality 23ZR1441200Natural Science Foundation of Shanghai Municipality 24ZR1450000
6 · The paper itself

Abstract

purposeAstrocyte reactivity is a key pathological feature and potential therapeutic target of Alzheimer's disease (AD), however, the optimal timing of its modulation remains unexplored. This study aims to combine

methodsPET imaging with

resultsIn 3xTg-AD mice of different ages, higher uptake of

conclusion

Indexed as

Alzheimer DiseaseAstrocytesDisease ProgressionFluorine RadioisotopesPositron-Emission TomographyAnimalsMaleMiceMice, TransgenicFluorine Radioisotopes18F-SMBT-1Alzheimer's diseaseAstrocyte-targeted therapyMolecular imagingReactive astrocytes

Identifiers

PMID40956407
PMCPMC12860820

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.