SynthesisWorld journal of urology2025
Sterile water injections for analgesia in renal colic: a meta-analysis of level 1 evidence.
Synthesis in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07378904 (Intradermal Sterile Water Injection Versus Intravenous Morphine for Renal Colic), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intradermal Sterile Water Injection Versus Intravenous Morphine for Renal Colic: A Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
- Diagnosis and Management of Urinary Stone Disease in Pregnancy: Integrating Current Guidelines with Emerging Evidence.Current urology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effectiveness of Sterile water injections (SWIs) for acute pain relief in renal colic.
methodsThis study was conducted in accordance with the Preferred Reporting items for Systematic Reviews and Meta-Analyses. MEDLINE, CINAHL, Web of Science and Cochrane were searched to identify randomised controlled trials (RCTs) comparing SWIs with placebo or other analgesics in renal colic patients. Data were pooled and analysed using random effects modelling with 95% confidence intervals (CIs).
resultsSix RCTs including 1322 renal colic patients were included, with 466 (35.2%) receiving SWIs. Patients receiving SWIs had comparable demographics and presenting features to the control groups, with control medications ranging from placebos, non-steroidal anti-inflammatories, and opioids. Self-reported pain scores at 30 min following intervention were lower in SWI than placebo (MD = - 4.63, 95% CI: - 5.16, - 4.10, P < 0.001) and other analgesics (MD = - 0.36, 95% CI: - 0.52, - 0.21, P < 0.001). The use of rescue analgesia was lower in those receiving SWIs compared to placebo (OR = 0.24, 95% CI: 0.10, 0.59, P = 0.002) and other analgesics (OR = 0.46, 95% CI: 0.29, 0.74, P = 0.001). No significant side effects were attributed to SWI use.
conclusionsSWIs demonstrated superior pain relief and reduced rescue analgesia requirements, compared to placebo and standard treatment, offering a promising alternative for patients where traditional options are unsuitable.
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Registered trials
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