Evidence map›Paper›PMID 40956344›Full record

ArticleDie Naturwissenschaften2025

The Impact of LINC-PINT polymorphisms on HNSCC risk in a Chinese han population.

Lingyu Kong, Wenjing Wang, Hang Meng, Mengnan Hou, Shan Wang, Wanli Ren, Hao Dai, Bin Li, Tianbo Jin

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In one paragraph

Article in Die Naturwissenschaften, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lingyu KongKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
Wenjing WangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
Hang MengKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
Mengnan HouKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
Shan WangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
Wanli RenDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Hao DaiDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Bin LiKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China. libinwhu@nwu.edu.cn.
Tianbo JinKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China. jintb@nwu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous carcinoma (HNSCC) is one of the most common malignant tumors in the upper gastrointestinal tract. Inherited genes are non-modifiable risk factors for HNSCC. This study aims to determine the association between LINC-PINT polymorphism and the risk of HNSCC risk in a Chinese Han population. Genomic DNA was extracted from the whole blood samples of 524 HNSCC patients and 517 healthy controls. The associations of LINC-PINT polymorphisms and HNSCC susceptibility were evaluated through logistic regression analysis. Our study showed that rs157916, rs16873842, and rs7781295 were related to an increased susceptibility to HNSCC. Stratification analyses demonstrated that rs157916 and rs7781295 were associated with an increased risk of HNSCC in age ≤ 46 years, men, and thyroid SCC. Rs16873842 and rs7801029 showed an enhanced risk of HNSCC in men. Additionally, rs16873842 and rs7781295 may increase the risk of Nasopharyngeal SCC. Moreover, the combination of rs7801029 and rs7781295 could serve as a predictive model for HNSCC. This study suggests that LINC-PINT polymorphisms may be correlated with an increased risk of HNSCC.

Indexed as

Genetic Predisposition to DiseaseHead and Neck NeoplasmsPolymorphism, Single NucleotideRNA, Long NoncodingSquamous Cell Carcinoma of Head and NeckAdultAgedCase-Control StudiesChinaEast Asian PeopleFemaleHumansMaleMiddle AgedRisk FactorsRNA, Long NoncodingGenetic SusceptibilityHead and neck squamous cell carcinomaLINC-PINTPolymorphismStratified Analysis

Identifiers

PMID40956344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.