Evidence map›Paper›PMID 40956292›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Phenylboronic Acid-Modified Copper Nanozymes as Nanoscavengers of Bacterial Polysaccharides Causing Acute Lung Injury.

Haojie Ge, Min Wang, Haijiao Xie, Xu-Lin Chen, Xianwen Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haojie GeDepartment of Burns, The First Hospital Affiliated of Anhui Medical University, Anhui Medical University, Hefei, Anhui, 230032, P. R. China.
Min WangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China.ORCID https://orcid.org/0000-0001-5012-9548
Haijiao XieHangzhou Yanqu Information Technology Co., Ltd, Hangzhou, 310003, P. R. China.
Xu-Lin ChenDepartment of Burns, The First Hospital Affiliated of Anhui Medical University, Anhui Medical University, Hefei, Anhui, 230032, P. R. China.
Xianwen WangDepartment of Burns, The First Hospital Affiliated of Anhui Medical University, Anhui Medical University, Hefei, Anhui, 230032, P. R. China.ORCID https://orcid.org/0000-0002-6343-440X

Funding

Anhui Key Research and Development Plan 202104j07020027Anhui Province Excellent Research and Innovation Team Project 2024AH010013Anhui Provincial Natural Science Foundation 2408085Y016Excellent Youth of Natural Science Research Projects in Anhui Province Universities 2023AH030060National Natural Science Foundation of China 82172204National Natural Science Foundation of China 82372517National Natural Science Foundation of China 82372552
6 · The paper itself

Abstract

Acute lung injury (ALI), especially burn-induced cases complicated by secondary infections and hyperinflammation, remains challenging to treat. This study developed 4-mercaptobenzoic acid (MPBA)-modified copper nanozymes (CuMPBA) to simultaneously combat bacterial infections and toxin-triggered immune overactivation. CuMPBA binds bacterial surface polysaccharides via boronate ester bonds, neutralizing lipopolysaccharides (LPS) and lipoteichoic acid (LTA). It demonstrates dual enzymatic activity: peroxidase (POD)-like and glutathione peroxidase (GPx)-like activities for antimicrobial effects. Additionally, CuMPBA disrupts Streptococcus pneumoniae (Sp) metabolism by interfering with thiamine utilization, amino acid synthesis, DNA processes, and energy production. In burn-ALI mice with secondary pneumonia, CuMPBA restored lung architecture, suppress TNF-α/IL-1β/IL-6 levels, and modulated inflammatory pathways by activating Nrf2 while inhibiting NF-κB. These synergistic mechanisms (precise bactericidal action combined with toxin neutralization) establish CuMPBA as a promising dual-target therapeutic strategy for complex burn-associated ALI. The multifunctionality of nanozymes addresses both infection control and inflammation resolution, offering new potential for managing this severe pathological condition.

Indexed as

Acute Lung InjuryAnti-Inflammatory AgentsBenzoatesMetal NanoparticlesPneumococcal InfectionsStreptococcus pneumoniaeSulfhydryl CompoundsAnimalsAnti-Bacterial AgentsBiofilmsDisease Models, AnimalEscherichia coliMethicillin-Resistant Staphylococcus aureusMicePolysaccharides, BacterialRandom Allocation4-mercaptobenzoateAnti-Bacterial AgentsAnti-Inflammatory AgentsBenzoatesPolysaccharides, BacterialSulfhydryl Compoundsacute lung injurycopper nanoparticlesnanozymespolysaccharidestarget bacteria

Identifiers

PMID40956292
PMCPMC12677591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.