Evidence map›Paper›PMID 40956269›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2025

Hypothalamic-Pituitary-Adrenal Axis Recalibration During Puberty Among Maltreated Youth: The Role of Caregiver Depression.

Sonya Negriff, Elana B Gordis, Melissa K Peckins

Abstract read
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In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sonya NegriffDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California. Electronic address: Sonya.x.negriff@kp.org.
Elana B GordisDepartment of Psychology, University at Albany, State University of New York, Albany, New York.
Melissa K PeckinsDepartment of Psychology, St. John's University, Queens, New York.

Funding

IMPACT OF NEGLECT ON ADOLESCENT DEVELOPMENTR01HD039129 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TRICKETT, PENELOPE K · 2000 to 2006
$3.4M
Childhood Maltreatment and Disease Risk in Young Adulthood: The Role of HPA Regulation in AdolescenceR01HD105691 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI Sonya L Negriff · 2022 to 2026
$3.2M
Linking DNA methylation with child maltreatment and mental health across adolescenceR01HD098161 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI NEGRIFF, SONYA L · 2020 to 2024
$3.1M
From Child Maltreatment to Adolescent Substance Abuse: Risks, Protective FactorsR01DA024569 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TRICKETT, PENELOPE K · 2009 to 2010
$1.5M
Physical Abuse and Child Aggression:Role of ANS ArousalK23HD041428 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORDIS, ELANA B · 2002 to 2006
$515k
NICHD NIH HHS K23 HD041428NICHD NIH HHS R01 HD039129NICHD NIH HHS R01 HD098161NICHD NIH HHS R01 HD105691NIDA NIH HHS R01 DA024569
6 · The paper itself

Abstract

purposeTo examine trajectories of hypothalamic-pituitary-adrenal (HPA) axis sensitivity, we tested growth models of cortisol reactivity before and during puberty using longitudinal data from maltreated and comparison adolescents. Moderating effects of parental depressive symptoms on pubertal cortisol reactivity slope tested for HPA axis recalibration.

methodsYouth (N = 454) completed 4 assessments across 10 years (Wave 1 M

resultsCortisol reactivity did not change before Tanner 3 but increased in the years following Tanner 3 in both girls and boys. The interaction was significant between parental depressive symptoms at Tanner 3 and post-Tanner 3 cortisol reactivity trajectory among those with PA/SA exposure prepuberty. DISCUSSION: The results indicate possible recalibration of the HPA axis where youth with childhood PA/SA exposure and benevolent family environments (i.e., no parental depressive symptoms, stable caregiver) appeared to regain the expected developmental pattern of increasing cortisol reactivity during puberty. This indicates puberty as a key developmental period to regulate HPA functioning and mitigate potential associated physical and mental health outcomes.

Indexed as

CaregiversChild AbuseDepressionHypothalamo-Hypophyseal SystemParentsPituitary-Adrenal SystemPubertyAdolescentChildFemaleHumansHydrocortisoneLongitudinal StudiesMaleHydrocortisoneCortisolHPA axisMaltreatmentParental depressive symptomsRecalibration

Identifiers

PMID40956269
PMCPMC12823048

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.