ArticleAnalytical chemistry2025
Paper-Based Fast-Flow Electrochemical Device Enabling Self-Calibrated and High-Throughput NADPH Measurements.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Paper-based microfluidic devices for electrochemical quantification of the explosive picric acid.Mikrochimica acta · 2026Article
- Microfluidic Paper-Based Devices at the Edge of Real Samples: Fabrication Limits, Hybrid Detection, and Perspectives.Micromachines · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microfluidic paper-based electrochemical devices (μPEDs) are transforming cost-effective and portable diagnostics. However, conventional μPEDs are limited to a single use, as the removal of analyzed solutions is challenging, preventing repeatable measurements. This study introduces a paper-based fast-flow electrochemical device (PFED) design that overcomes this limitation, enabling multiple detections within a single device without requiring external power. Unlike traditional μPEDs, the PFED integrates a plastic hollow channel with a wax-printed channel, ensuring that fluid flow is not solely dependent on capillary action. This enhanced configuration accelerates liquid transport, facilitates rapid solution exchange, and significantly improves device repeatability. Additionally, the PFED, coupled with a copper phthalocyanine-modified screen-printed graphene electrode (CuPc/SPGE), introduces a novel electrochemical sensing strategy for NADPH detection. Under optimized conditions, the sensor achieved a detection limit of 3.75 μM and a limit of quantitation of 12.5 μM. The integration of a fast-flow platform with electrochemical detection not only enables repeatable and automated measurements but also provides superior self-calibration capabilities. Finally, the PFED was successfully applied to G6PD deficiency assessment, where NADPH monitoring enabled the differentiation of healthy and deficient enzyme variants. These advancements position the PFED as a highly versatile and efficient tool for diverse analytical applications.
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Registered trials
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