Evidence map›Paper›PMID 40955905›Full record

ArticleeLife2025

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes.

Erika Tsingos, Advaita M Dick, Baubak Bajoghli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erika Tsingos *Computational Developmental Biology Group, Institute of Biodynamics and Biocomplexity, Utrecht University, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-7267-160X
Advaita M Dick *Department of Hematology, Oncology, Immunology, and Rheumatology, University, Hospital of Tübingen, Tübingen, Germany.
Baubak BajoghliDepartment of Hematology, Oncology, Immunology, and Rheumatology, University, Hospital of Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0002-7368-7523

Funding

Deutsche Forschungsgemeinschaft BA 5766/5-1Madeleine Schickedanz Kinderkrebsstiftung D.30.28666Nederlandse Organisatie voor Wetenschappelijk Onderzoek VI.Veni.222.323
6 · The paper itself

Abstract

The discovery of genetic alterations in patient samples over the last decades has reinforced a cell-autonomous view of proliferative expansion during T-cell acute lymphoblastic leukemia (T-ALL) development in the thymus. However, the potential contribution of non-cell-autonomous factors, particularly the impact of thymic epithelial cells (TECs) within the thymic niche during the initiation phase, remains unexplored. In this study, we combine a cell-based computational model of the thymus with complementary in vivo experiments in medaka (

Indexed as

Cell ProliferationPrecursor T-Cell Lymphoblastic Leukemia-LymphomaThymocytesThymus GlandAnimalsComputer SimulationEpithelial CellsHumansMutationOryziasReceptors, Interleukin-7Receptors, Interleukin-7cancer biologycell-based modelcomputational biologymedakamultiscale modeloryzias latipessystems biologyT-ALLthymocytesthymus

Identifiers

PMID40955905
PMCPMC12440356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.