ArticlePlant biotechnology journal2026
De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase.
Bo He, Yanhao Hu, Xu He, Wang Chen, Wei Yan, Xin Zang, Jiahai Zhou, Yonghao Ye
Abstract read
In one paragraphArticle in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Bo HeState Key Laboratory of Agricultural and Forestry Biosecurity, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0002-7739-5579 Yanhao HuState Key Laboratory of Agricultural and Forestry Biosecurity, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Xu HeState Key Laboratory of Agricultural and Forestry Biosecurity, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Wang ChenState Key Laboratory of Agricultural and Forestry Biosecurity, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Wei YanState Key Laboratory of Agricultural and Forestry Biosecurity, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Xin ZangState Key Laboratory of Chemical Biology, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, CAS, Shanghai, China.
Jiahai ZhouState Key Laboratory of Chemical Biology, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, CAS, Shanghai, China.
Yonghao YeState Key Laboratory of Agricultural and Forestry Biosecurity, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0003-3538-6006 Funding
National Key Research and Development Program of China 2021YFD1700101National Natural Science Foundation of China 32202356National Natural Science Foundation of China 32472625Natural Science Foundation of Jiangsu Province BK20221002
6 · The paper itselfAbstract
Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched-chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron-sulfur clusters and hydrophobic interactions with Tyr215 and Phe181 are crucial for inhibitor binding. Based on this model, we designed and synthesised derivatives 4aa-4bb with a benzoxazinone ring. Compound 4bb effectively inhibited Arabidopsis seed germination at 50 μg/mL, reversible by BCAA supplementation. In vitro, 4bb showed a stronger binding affinity to DHAD (K
Indexed as
BenzoxazinesHerbicidesHydro-LyasesArabidopsisGerminationHumansPlant WeedsSeedsBenzoxazinesHerbicidesHydro-Lyasesbenzoxazinonebranched‐chain amino acidsdihydroxyacid dehydratase (DHAD)herbicidal targetstructure‐based drug design
Identifiers
PMID40955878
PMCPMC12906841
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