Evidence map›Paper›PMID 40955849›Full record

ArticleDevelopment (Cambridge, England)2025

Drosophila Dpp and BMP signaling directly regulates dpp transcription for optimal ligand production.

Yan Zhang, Ying Feng, Xiaolei Ye, Yi Lin, Ling Zeng, Yuting Luo, Lin Zhou, Chenghao Shen, Weiqi Hu, Dong Yan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan ZhangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.ORCID 0000-0002-4971-0391
Ying FengState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.ORCID 0000-0001-6687-266X
Xiaolei YeState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Yi LinState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Ling ZengState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Yuting LuoState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Lin ZhouState Key Laboratory of Genetic and Development of Complex Phenotypes, School of Life Sciences, Fudan University, Shanghai 200438, China.
Chenghao ShenState Key Laboratory of Genetic and Development of Complex Phenotypes, School of Life Sciences, Fudan University, Shanghai 200438, China.
Weiqi HuState Key Laboratory of Genetic and Development of Complex Phenotypes, School of Life Sciences, Fudan University, Shanghai 200438, China.
Dong YanState Key Laboratory of Genetic and Development of Complex Phenotypes, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID 0000-0002-3786-5708
Xinhua LinState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.ORCID 0000-0002-1063-749X

Funding

National Natural Science Foundation of China 31900529Natural Science Foundation of Zhejiang Province LY21C070003
6 · The paper itself

Abstract

Precise control of morphogen dosage in the source is essential for establishing developmental patterning and maintaining signaling stability. Here, we demonstrate that in Drosophila wing imaginal discs Decapentaplegic and BMP (Dpp/BMP) signaling modulates expression of the ligand Dpp through direct transcriptional auto-regulation. The results show that reduction of Dpp/BMP signaling upregulates dpp transcription, whereas enhanced signaling represses it. This transcriptional negative-feedback mechanism primarily depends on the BMP-silencer-element (BMP-SE) complex binding to BMP-SE motifs at the dpp downstream distal cis-regulatory region. We validated this mechanism through BMP-SE complex interference and BMP-SE motif disruption assays. Our findings extend the morphogen source-sink theory by uncovering that the Dpp/BMP signaling pathway dynamically balances Dpp dosage via transcriptional auto-modulation, thereby ensuring optimal ligand production for signaling homeostasis.

Indexed as

Bone Morphogenetic ProteinsDrosophila melanogasterDrosophila ProteinsSignal TransductionTranscription, GeneticAnimalsGene Expression Regulation, DevelopmentalImaginal DiscsLigandsWings, AnimalBone Morphogenetic Proteinsdpp protein, DrosophilaDrosophila ProteinsLigandsDecapentaplegic (dpp)Dpp/BMP signalingDrosophila melanogasterLigand dosageMorphogen gradientNegative feedback

Identifiers

PMID40955849
PMCPMC12633792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.