Evidence map›Paper›PMID 40955787›Full record

ArticleeLife2025

Regulating closure of the neural tube in humans.

Leon Qarawani, Jacob H Hanna

Abstract readEditorial
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leon QarawaniDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID https://orcid.org/0009-0009-9342-7030
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID https://orcid.org/0000-0003-2042-9974

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.

Indexed as

Gene Expression Regulation, DevelopmentalNeural TubeGene Knockdown TechniquesHumansOrganoidsbioengineeringCRISPRidevelopmental biologyhumanmorphogenesisneural tube closureorganoidsstem cells

Identifiers

PMID40955787
PMCPMC12440350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.