Evidence map›Paper›PMID 40955770›Full record

Observational studyPediatric pulmonology2025

Respiratory Muscle Strength in Healthy Children Aged 6 Years and Under: An Observational Study.

Kayley Noxell, Emily Acquaye, Vicky MacBean

Abstract readObservational Study
In one paragraph

Observational study in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kayley NoxellTherapeutic Services Ltd Physiotherapy, St John's, St. John's, Newfoundland, Canada.
Emily AcquayeDepartment of Health Sciences, Brunel University of London, Uxbridge, UK.
Vicky MacBeanDepartment of Health Sciences, Brunel University of London, Uxbridge, UK.ORCID 0000-0003-0268-2693

Funding

This study was funded by Astellas Gene Therapies (previously Audentes Therapeutics Inc), including provision of study equipment.
6 · The paper itself

Abstract

study questionMeasurement of respiratory muscle strength is important in the assessment and management of neuromuscular diseases. Reference data are essential for interpretation of clinical findings, but are lacking in infants and young children. This study aimed to provide reference data for maximum inspiratory (PImax) and maximum expiratory (PEmax) pressures in children aged 6 years and under. MATERIALS AND

methodsHealthy, term-born children were eligible for inclusion. Age, height, weight and BMI were recorded, and height/weight/BMI-for-age percentiles calculated. PImax and PEmax were measured using a tight-fitting face mask attached to a pressure transducer during maximal inspiratory and expiratory efforts respectively, induced via crying in younger participants and volitionally in older children. The greatest pressure was reported from three values within 20% of one another. Repeat measurements were obtained within a week where possible.

resultsSixty-nine children aged 0.08-6.85 years were recruited, from whom technically-acceptable PImax and PEmax data were obtained in 45 and 38 cases respectively. PImax was significantly and inversely related to age (Spearman's rho -0.339, p = 0.046); PEmax was not related to any anthropometric characteristics. Neither PImax or PEmax differed between male and female participants. Predicted PImax was 120 + (-3.89xage); mean (SD) PEmax was 80.3 (21.7) cmH ANSWER TO THE STUDY QUESTION: This study provides the first contiguous reference range from infancy through to school age. Reference data are provided for PImax and PEmax along with information on repeatability.

Indexed as

Muscle StrengthRespiratory MusclesChildChild, PreschoolExhalationFemaleHumansInfantMaleReference Valueschildinfantreference datarespiratory muscles

Identifiers

PMID40955770
PMCPMC12439322

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.