Evidence map›Paper›PMID 40955726›Full record

ArticleJournal of the American Geriatrics Society2025

Patients With Dementia Undergoing High-Risk Inpatient Surgery Have Poor Outcomes.

Samir K Shah, Lingwei Xiang, Rachel R Adler, Clancy J Clark, Zara Cooper, Emily Finlayson, Susan L Mitchell, Dae Hyun Kim, Kueiyu Joshua Lin, Stuart R Lipsitz and 1 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Racial and Sex Differences in Postoperative Mortality Between Patients With Versus Without Dementia.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samir K ShahDivision of Vascular Surgery, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-6474-1455
Lingwei XiangCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rachel R AdlerCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Clancy J ClarkDivision of Surgical Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Zara CooperCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Emily FinlaysonDepartment of Surgery, Phillip R. Lee Institute for Health Policy Studies, University of California, San Francisco, California, USA.
Susan L MitchellHebrew SeniorLife, Arthur and Hinda Marcus Institute for Aging Research, Boston, Massachusetts, USA.
Dae Hyun KimHebrew SeniorLife, Arthur and Hinda Marcus Institute for Aging Research, Boston, Massachusetts, USA.ORCID 0000-0001-7290-6838
Kueiyu Joshua LinDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Stuart R LipsitzCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Joel S WeissmanCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

Understanding and Improving Surgical Decision-Making for Persons Living with Dementia, their Family Caregivers, and their Providers: A Mixed Methods StudyR01AG067507 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISSMAN, JOEL S. · 2020 to 2024
$4.4M
NIA NIH HHS R01 AG067507NIA NIH HHS R01AG067507
6 · The paper itself

Abstract

backgroundSurgery is common among patients living with dementia, and understanding outcomes may help decision-making. We compared patients' and utilization outcomes after high-risk surgery among patients with and without dementia.

methodsIn this retrospective national cohort study, we compared outcomes of Medicare fee-for-service beneficiaries 66 years or older who underwent high-risk inpatient surgery (i.e., with an inpatient mortality of at least 1%) from January 1, 2017 to September 30, 2018. We examined 90- and 30-day all-cause mortality, major complications, discharge to a higher level of care, intensive end-of-life interventions, and prolonged skilled nursing facility (SNF) stay. We used generalized estimating equations regression modeling and competing risks analysis.

resultsAmong 19,998,187 beneficiaries, we identified 859,570 who had fee-for-service coverage and were 66 years or older at the time of a high-risk surgery. Of these, 124,822 (14.5%) had a diagnosis of dementia. Female sex accounted for 81,252 (65.1%) of the dementia cohort. Four of five of the most common procedures were related to femur fracture and cardiac surgery in the dementia and non-dementia cohorts. Ninety-day mortality was worse among patients with dementia: 22.8% versus 9.3% (adjusted odds ratio [aOR] 1.82, 95% confidence interval [CI] 1.78-1.85). Patients with dementia were also more likely to have major complications (51.6% vs. 38.5%, aOR 1.19, 95% CI 1.17-1.20), be discharged to a higher level of care (75.1% vs. 41.3%, aOR 1.49, 95% CI 1.44-1.53), and have a prolonged SNF stay (3.7% vs. 1.4%, aOR 1.80, 95% CI 1.69-1.91). Although patients with ADRD were overall less likely to receive intensive interventions during the index admission and at 90 days, they were more likely to receive feeding tubes (aOR 1.22, 95% CI 1.17-1.28).

conclusionPersons living with dementia experience a broad range of worse outcomes after high-risk surgery compared to those without dementia. These data may be used for decision-making.

Indexed as

Cardiac Surgical ProceduresDementiaFemoral FracturesHealth Services for the AgedPostoperative ComplicationsAgedAged, 80 and overFemaleHumansInpatientsMaleRiskUnited Statesdementiahigh‐risk surgeryMedicare

Identifiers

PMID40955726
PMCPMC12965178

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.