Evidence map›Paper›PMID 40955723›Full record

SynthesisJournal of digestive diseases

Efficacy and Safety of Linaclotide as an Adjunct to Polyethylene Glycol in Bowel Preparation: A Meta-Analysis.

Muhammad Shahzil, Fariha Hasan, Ali Akram Qureshi, Zainab Jamil, Talha Kashif, Muhammad Saad Faisal, Taha Bin Arif, Ammad Javaid Chaudhary, Umer Farooq, Hassam Ali and 1 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of digestive diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad ShahzilDepartment of Internal Medicine, Penn State Health Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4010-7545
Fariha HasanDepartment of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA.
Ali Akram QureshiDepartment of Medicine, King Edward Medical University, Lahore, Punjab, Pakistan.
Zainab JamilDepartment of Medicine, King Edward Medical University, Lahore, Punjab, Pakistan.
Talha KashifDepartment of Medicine, King Edward Medical University, Lahore, Punjab, Pakistan.
Muhammad Saad FaisalDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.ORCID https://orcid.org/0009-0004-4785-7922
Taha Bin ArifDepartment of Internal Medicine, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
Ammad Javaid ChaudharyDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Umer FarooqDivision of Gastroenterology & Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Hassam AliDepartment of Gastroenterology, ECU Health, Greenville, North Carolina, USA.ORCID https://orcid.org/0000-0001-5546-9197
John M LevenickDepartment of Gastroenterology and Hepatology, Penn State Health Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA.

Funding

Pennsylvania State University
6 · The paper itself

Abstract

objectivesLinaclotide, a guanylyl cyclase-C agonist, may enhance efficacy and tolerability when combined with polyethylene glycol (PEG) for bowel preparation. This meta-analysis evaluated linaclotide plus PEG versus PEG alone for bowel preparation prior to colonoscopy.

methodsRandomized controlled trials (RCTs) including adults undergoing colonoscopy that compared linaclotide plus PEG with PEG alone for bowel preparation were identified via database search up to March 2024. Statistical analysis was performed in RevMan Web using random-effects models.

resultsEleven RCTs were analyzed. Adequate bowel preparation rate was comparable (risk ratio [RR] 1.01, 95% confidence interval [CI] 0.98-1.04; I

conclusionsLinaclotide with PEG provides comparable overall bowel cleansing to PEG alone while reducing adverse events and improving patient acceptance. Importantly, 2-L PEG plus linaclotide was non-inferior compared with 3-L PEG, whereas 3-L PEG plus linaclotide showed superiority over 3-L PEG alone, supporting its use in low-volume bowel preparation strategies.

Indexed as

CatharticsColonoscopyGuanylyl Cyclase C AgonistsPeptidesPolyethylene GlycolsHumansMaleRandomized Controlled Trials as TopicCatharticsGuanylyl Cyclase C AgonistslinaclotidePeptidesPolyethylene Glycolsbowel preparationcolonoscopycolorectal neoplasmslinaclotidepolyethylene glycols

Identifiers

PMID40955723
PMCPMC12492060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.