ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
The Role of Centrosome Misorientation and miR-1270 in Impaired Endothelial Cell Migration in Preeclampsia.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Role of Centrosome Misorientation and miR-1270 in Impaired Endothelial Cell Migration in Preeclampsia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Preeclampsia is a serious pregnancy-related disorder that poses significant health risks to the mother and offspring. A key aspect of preeclampsia is impaired endothelial cell migration, which is essential for the repair and integrity of the vasculature. Preeclamptic endothelial progenitor cells (EPC) exhibit defects in migration, although the precise molecular mechanisms underlying these defects remain unclear. Cellular spatial organization, such as centrosome orientation, regulates the migration process by influencing cell polarity and movement. Epigenetic changes in preeclampsia may disrupt these processes and thus impair endothelial function. We recently described the role of microRNA (miR)-1270 in preeclamptic EPC, linking its dysregulated expression to impaired EPC motility. Here, we demonstrate that endothelial cell migration defects in preeclampsia, along with reduced miR-1270 levels, are accompanied by changes in centrosome orientation. This study provides novel insights into the molecular consequences of preeclampsia and its detrimental effects on endothelial dynamics.
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