ArticleMaterials today. Bio2025
AIE-driven photothermal nanotrigger-activated multifunctional injectable hydrogel for maxillofacial infection control.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Synergistic phototherapy and CaBioactive materials · 2026Article
- NIR-absorbing organic charge transfer complexes for photothermal antibacterial therapy and wounds healing.Materials today. Bio · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
The treatment of maxillofacial infections and wounds remains highly challenging due to the risk of facial deformities and the resulting psychological trauma. Furthermore, the irregular geometry and complex anatomical structures of maxillofacial wounds hinder effective clinical intervention. Therefore, the development of controllable and multifunctional composite hydrogels is highly desirable for promoting tissue regeneration, particularly in cases involving irregularly shaped tissue defects. In this study, we developed AIE-induced photothermal nanotrigger strategy for fabricating injectable multifunctional hydrogel zwitterionic wound dressing. This antibacterial composite zwitterionic hydrogel (TSD NPs@Gel) was synthesized using sulfobetaine methacrylate (SBMA) as the monomer, N,N'-methylenebisacrylamide (MBAA) as the crosslinker, and ammonium persulfate (APS) as the initiator. By incorporating aggregation-induced emission (AIE) nanoparticles (TSD NPs), we leveraged their excellent photothermal properties to achieve a "photothermal self-catalysis (PSC)" effect. Under light irradiation, TSD NPs generated heat, which accelerated the decomposition of APS into free radicals, thereby promoting the polymerization between the monomer and crosslinker. This innovative approach eliminated the need for traditional chemical catalysts and enabled the efficient preparation of the hydrogel. This hydrogel exhibits synergistic antibacterial effects through photothermal (PTT) and photodynamic (PDT) therapies. Under 660 nm laser irradiation, TSD NPs@Gel efficiently generates PTT and PDT effects, demonstrating significant bactericidal efficacy against both Gram-positive bacteria (
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