Evidence map›Paper›PMID 40955318›Full record

ReviewJournal of blood medicine2025

Journeying Towards Excellence in the Care of Patients with Haemophilia and Other Inherited Bleeding Disorders From a Developing World: Insights From Tanzania.

Stella Samson Rwezaula, Samson D Mtoba, Rashid A Gosse, Rebecca W Mwakichako, Abdallah Raphael Makalla, Martha Loiseyeki Bruckman, Luhongedzo Gerson Matandala, Linda Alphey Shao, Hedwiga Francis Swai, Michelle Sholzberg and 3 more

Abstract readReview
In one paragraph

Review in Journal of blood medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stella Samson RwezaulaMuhimbili National Hospital, Dar Es Salaam, Tanzania.ORCID 0000-0003-1595-0749
Samson D MtobaMuhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.
Rashid A GosseMuhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.ORCID 0000-0002-4216-4551
Rebecca W MwakichakoMuhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.ORCID 0009-0005-5290-2457
Abdallah Raphael MakallaMuhimbili National Hospital, Dar Es Salaam, Tanzania.
Martha Loiseyeki BruckmanMuhimbili National Hospital, Dar Es Salaam, Tanzania.
Luhongedzo Gerson MatandalaMuhimbili National Hospital, Dar Es Salaam, Tanzania.
Linda Alphey ShaoMuhimbili National Hospital, Dar Es Salaam, Tanzania.
Hedwiga Francis SwaiMuhimbili National Hospital, Dar Es Salaam, Tanzania.
Michelle SholzbergSt. Michael's Hospital, Toronto, Canada.
Jerome TeitelSt. Michael's Hospital, Toronto, Canada.ORCID 0000-0001-6455-8167
Amos Rodger MwakigonjaMuhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.
Oluyemi AkinloyeCenter for Genomics of Non-Communicable Diseases and Personalized Health Care, University of Lagos, Lagos, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Haemophilia, an X-linked recessive bleeding disorder caused by mutations in the Methods: This is a comprehensive review of national program reports, registry data from the Haemophilia Society of Tanzania, and interviews with key personnel directly involved in the development of haemophilia services between 2021 and April 2025. Results: Between 2021 and 2025, Tanzania made significant strides in strengthening haemophilia care. A multidisciplinary workforce was trained both locally and internationally in specialized diagnosis, treatment, and management of haemophilia and other inherited bleeding disorders. Fourteen haemophilia clinics were established, including a national comprehensive clinic at Muhimbili National Hospital and satellite clinics across zonal and regional hospitals, providing screening, diagnosis, and comprehensive care. As of 17th April 2025, a total of 473 patients had been registered and were receiving structured care through this network. Conclusion: The integration of specialized haematological training, stakeholder engagement, decentralization of services through 14 clinics, and the development of a national registry and clinical guidelines have markedly enhanced Tanzania's capacity to diagnose and manage haemophilia and other inherited bleeding disorders. Moving forward, it is imperative to expand regional coverage, intensify community-based awareness and screening initiatives, strengthen capacity building and research efforts, and establish a specialized centre of excellence dedicated to advancing haemophilia care, professional training, research, and innovation.

Indexed as

excellencehaemophiliainherited bleeding disordersjourneyingpatient careTanzania

Identifiers

PMID40955318
PMCPMC12433640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.