ReviewNature and science of sleep2025
Association Between Obstructive Sleep Apnea and Reflux Disease: A Systematic Review and Meta-Analysis.
Review in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Obstructive sleep apnea, CPAP therapy, and gastroesophageal reflux symptoms: evidence from a prospective cohort study.Frontiers in neurologyArticle
- Association Between Laryngopharyngeal Reflux and the Severity of Obstructive Sleep Apnea.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Obstructive sleep apnea (OSA) and gastroesophageal reflux disease (RD) are two common yet frequently co-occurring conditions that significantly impact sleep quality and overall health. While a growing body of evidence suggests a potential link between these disorders, the nature and strength of their relationship remain unclear. This systematic review and meta-analysis aims to comprehensively evaluate the association between OSA and RD, focusing on the incidence of RD in OSA patients and the potential impact of RD on sleep parameters, including sleep stages and apnea severity. Methods: We systematically searched PubMed, Embase, the Cochrane Library, and Scopus databases to identify relevant studies for this review. Eligible studies had to investigate the association between obstructive sleep apnea (OSA) and gastroesophageal reflux disease (RD) in adult populations. The primary outcomes assessed were the incidence of RD in OSA patients, as well as the impact of RD on sleep parameters, including sleep stages, apnea severity, and the Epworth Sleepiness Scale (ESS). Results: Totally 49 studies were included in this analysis. A modest association between obstructive sleep apnea (OSA) and the increased incidence of gastroesophageal reflux disease (RD), with a pooled relative risk of 1.23 (95% CI: 1.00, 1.52), although this did not reach statistical significance (p = 0.056). A trend towards increased reflux symptoms in severe OSA patients compared to mild OSA was noted (p=0.036). Patients with RD exhibited significantly lower sleep efficiency (p=0.003) and reduced oxygen saturation (p<0.001). Heterogeneity analysis indicated moderate variability across studies, primarily due to differences in patient characteristics and OSA severity. Conclusion: A certain association between obstructive sleep apnea (OSA) and gastroesophageal reflux disease (RD) was observed, but this association did not reach statistical significance. RD was significantly associated with reduced sleep efficiency, but no significant relationship was found between RD and OSA severity levels. While RD may influence early sleep stages (eg, N1), this effect remains inconclusive due to limited and variable supporting data. These findings highlight the need for further research to clarify the nature and direction of the OSA-RD relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.