ReviewCureus2025
Effects of Dexmedetomidine Use on the Renal Function of Elderly Patients Undergoing Laparoscopic Surgery: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative acute renal injury (ARI) is a common complication found in patients after laparoscopic surgery. This study aims to review the literature systematically to check the effect of dexmedetomidine (DEX) on ARI. A systematic review was conducted, encompassing abstracts published from January 2016 to August 2024, focusing on patients aged 60 years or older undergoing laparoscopic surgery. The focus of this study was on dexmedetomidine, which was used alone or with other anesthetics during the time around surgery, at any dose. The comparator of interest was a placebo or any perioperative medication used for the same purpose. ARI, urinary output, and length of stay (LOS) were the outcomes of interest. The studies of interest were clinical trials. Remote database searches were performed at PubMed, SCOPUS, Web of Science, Embase, and Cochrane, as well as full manuscript bibliographies. The risk of bias was assessed with Cochrane's RoB2 and result confidence was assessed with Grading of Recommendations Assessment, Development and Evaluation (GRADE). We analyzed 13 studies. A consistent but not significant nephroprotective effect of DEX was observed. A neutral effect was observed in urinary output and LOS, and there is evidence of reporting bias for LOS. The confidence in these findings is either poor or moderate. The use of DEX in the elderly population undergoing laparoscopy surgeries did not reduce the LOS or urinary output, but there is moderate confidence that it has a potential nephroprotective effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.