ReviewAnnals of medicine2025
The origin of circulating microbial DNA in the blood: where does it come from?
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The leaky gut and microbiome in critical illness: emerging insights into microbial "translocation".Current opinion in critical care · 2026Review
- Microbiota in the Tumor Metastatic Cascade: Emerging Evidence Across Invasion, Circulation, and Colonization.International journal of molecular sciences · 2026Review
- The best from both disciplines: integrating human and microbial signatures from whole genome sequencing to advance cancer diagnostics.mSystems · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating microbial DNA (cmDNA) is a significant biomarker involved in normal physiology, immunity, disease diagnosis, and pathogenesis. Its origin in peripheral blood has sparked extensive discussions and generated numerous hypotheses.
aimThis review explores four potential sources of cmDNA in the blood and analyzes research limitations and future prospects.
resultsFour potential sources are collated and analyzed: exogenous microbes or DNA entering the peripheral blood after barrier damage; residual pathogen DNA remaining after infectious diseases; microbial translocation from sites such as the oral and intestinal mucosa into the bloodstream; and the extracellular vesicle delivery system, where microorganisms release vesicles to transfer DNA.
conclusionsThe potential sources of cmDNA in the blood are not mutually exclusive and may be multifaceted, depending on an individual's health condition, sampling time, and contamination control. In-depth study of these sources will open new avenues for early disease detection, precise diagnosis, and prognosis assessment, and encourage further exploration in this promising field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.