Evidence map›Paper›PMID 40955101›Full record

SynthesisInternal medicine journal2025

Prevalence of vasculitis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies and spondyloarthritis in Australia: a systematic review and meta-analysis.

L Roper, E Cameron, T Yu, N Li, M Parker, N Nassar, M Nikpour

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Internal medicine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L RoperSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-8756-5295
E CameronDepartment of Rheumatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
T YuDepartment of Rheumatology, Westmead, Blacktown and Auburn Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia.
N LiSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
M ParkerSydney Musculoskeletal Research Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
N NassarLeeder Centre for Health Policy, Economics and Data, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
M NikpourSydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.

Funding

National Health and Medical Research Council 1176538National Health and Medical Research Council 2038603
6 · The paper itself

Abstract

backgroundSystemic autoimmune rheumatic diseases (SARDs), including vasculitis, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), spondyloarthritis (SpA), Sjogrens disease (SjD) and mixed connective tissue disease (MCTD), are rare but associated with substantial morbidity and healthcare burden. Their clinical heterogeneity and diagnostic complexity pose challenges for epidemiological study.

objectiveTo summarise Australian data on the incidence or prevalence of the SARDs listed above.

methodsScientific databases were searched in July 2024. Studies reporting SARD incidence or prevalence in the general Australian population were included. Where three or more studies of the same disease existed within a comparable population, which were not at high risk of bias (Hoy Tool), a random effects model was fitted.

resultsFrom 1357 publications, 58 were included, on: vasculitis (16), SLE (14), RA (10), SSc (nine), IIM (six) and SpA (three), with none on SjD or MCTD identified. Meta-analysis was possible in ANCA-associated vasculitis (AAV) (incidence 10.80 per million person-years), SLE (prevalence 57.86 per 100 000), lupus nephritis (prevalence 11.20 per 100 000, incidence 1.02 per 100 000 person-years), SSc (prevalence 25.58 per 100 000), IIM (incidence 9.96 per million person-years) and inclusion body myositis (prevalence 27.73 per million). Data were limited for paediatric populations and specific at-risk groups (e.g. Australians of Asian heritage).

conclusionAustralia may have above-average prevalence of SLE and SSc and geographic variation in SSc and AAV. Key research gaps include: (1) sparse data for non-AAV vasculitis, RA, SpA, SjD, MCTD and children; (2) limited validated algorithms to identify SARDs in administrative health data; and (3) a need for large-scale spatial studies to detect disease clusters.

Indexed as

Arthritis, RheumatoidLupus Erythematosus, SystemicMyositisScleroderma, SystemicSpondylarthritisVasculitisAustraliaHumansIncidencePrevalenceadministrative health dataAustraliameta‐analysisprevalencesystematic reviewsystemic autoimmune rheumatic diseases

Identifiers

PMID40955101
PMCPMC12704404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.