Evidence map›Paper›PMID 40955058›Full record

ArticleGut microbes2025

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses.

Pritha Chatterjee, Marianne R Spalinger, Charly Acevedo, Alina N Santos, Casey M Gries, Salomon M Manz, Vinicius Canale, Ali Shawki, Anica Sayoc-Becerra, Hillmin Lei and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Pritha ChatterjeeDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Marianne R SpalingerDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Charly AcevedoDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Alina N SantosDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Casey M GriesDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Salomon M ManzDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.ORCID 0000-0003-1062-5189
Vinicius CanaleDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Ali ShawkiDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Anica Sayoc-BecerraDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Hillmin LeiDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Meli'sa S CrawfordDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.
Lars EckmannDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
James BornemanDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA, USA.
Declan F McColeDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.ORCID 0000-0002-6286-0802

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
Tyrosine Phosphatase Regulation of Mucosal Macrophage-Epithelial Cell Cross-talkR01AI153314 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2020 to 2024
$2.5M
Immune function and mechanism of Tim3 expression and Tim3+ T cells in TB & HIV+TBR01AI106590 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHEN, ZHENG W · 2013 to 2015
$600k
Inflammatory Bowel Disease Susceptibility Gene Regulation of AnemiaR21AI152017 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2021 to 2022
$428k
NIAID NIH HHS R01 AI106590NIAID NIH HHS R01 AI153314NIAID NIH HHS R21 AI152017NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK091281
6 · The paper itself

Abstract

Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 (

Indexed as

Epithelial CellsEscherichia coliEscherichia coli InfectionsIntestinal MucosaProtein Tyrosine Phosphatase, Non-Receptor Type 2AnimalsCytokinesFemaleGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLMice, KnockoutCytokinesProtein Tyrosine Phosphatase, Non-Receptor Type 2Ptpn2 protein, mouseAdherent-invasive E. coli (AIEC)Antimicrobial PeptideBarrier FunctionInterleukin-22Intestinal PermeabilityPathobiontTight Junctions

Identifiers

PMID40955058
PMCPMC12445515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.