ArticleDevelopment and psychopathology2025
Maltreatment effects on cognitive control functional connectivity across adolescence: Prospective links to young adult mental health.
Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that childhood adversity is associated with both negative physical and mental health outcomes. Recent research posits that 1) there may be developmental periods for which the effects of adversity are most influential on brain development and 2) abuse and neglect may be associated with different developmental mechanisms linking psychopathology. This study used seven years of longitudinal data to investigate how abuse and neglect during three developmental periods (early childhood, middle childhood, and adolescence), as well as chronicity of maltreatment across these developmental periods, are associated with young adult mental health outcomes (ages 20-21), and how changes in adolescent task-based functional connectivity during cognitive control (between ages 14-15 and 18-20 years) may mediate these associations. Hypothesized mediation models were tested via structural equation modeling (SEM). Significant indirect effects indicated that chronic abuse predicted higher depressive symptoms and higher substance use through stronger dACC-insula connectivity. In contrast, significant indirect effects revealed that neglect during adolescence predicted lower substance use and lower depressive symptoms through weaker dACC-insula connectivity. These results suggest that differential patterns of connectivity changes within the salience network during cognitive control may be associated with risk and resilience for future depression and substance use in young adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.