ArticlePsycho-oncology2025
Establishing Diagnostic Cut-Off Scores for the Perceived Cognitive Impairment Subscale of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 in Portuguese Cancer Survivors.
Article in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07755839 (CanCOG® - Cognitive Rehabilitation in Cancer), which is not on this map. Cited by 2 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CanCOG® - Cognitive Rehabilitation in Cancer: A Protocol for a Multicenter Pilot Randomized Controlled Trial With Non-central Nervous System Cancer Survivors
Who cites it
2 citing papers in PubMed.
- Development and Preliminary Psychometric Evaluation of the ACRIS-CS: A Theory-Based Measure of Prospective Acceptability of Cognitive Rehabilitation in Cancer Survivors.Journal of clinical medicine · 2026Article
- Establishing Diagnostic Cut-Off Scores for the Perceived Cognitive Impairment Subscale of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 in Portuguese Cancer Survivors.Psycho-oncology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveCancer-related cognitive impairment (CRCI) negatively impacts the quality of life of non-central nervous system (non-CNS) cancer survivors. Detecting these cognitive changes remains challenging due to the lack of standardized CRCI classification and detection criteria. This study aimed to establish cut-off scores for the perceived cognitive impairment (CogPCI) subscale of the European Portuguese version of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 (FACT-Cog-v3).
methodsWe analyzed data from 266 Portuguese-speaking non-CNS cancer survivors and performed a receiver operating characteristic (ROC) curve analysis to evaluate the diagnostic validity of the CogPCI subscale of the FACT-Cog-v3 to detect meaningful perceived CRCI.
resultsThe CogPCI subscale demonstrated good screening performance in identifying individuals with and without clinically relevant CRCI, as indicated by a moderate-to-high area under the curve (AUC) score of 0.87. A suggested optimal cut-off score of < 51 provided good sensitivity (81.2%) and specificity (78.9%) for CogPCI to differentiate between the two groups. Over half of the participants reported significant cognitive complaints, highlighting the urgent need for standardized cognitive assessments in oncology.
conclusionsThis study contributes valuable insights into the early and fast detection and intervention of CRCI in Portugal. Using a brief, validated, self-report cognitive assessment tool can enhance the management of cognitive symptoms in non-CNS cancer survivors.
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