Evidence map›Paper›PMID 40954549›Full record

ArticleJournal of cellular and molecular medicine2025

HIF-1α Promotes the Confined Migration of Gastric Cancer Cells by Modulating Phosphatidylcholine Metabolism.

Ming Zhou, Kanger Shen, Ziyi Huang, Qin Zhan, Jiayu Wang, Xiaozhe Mao, Tongguo Shi, Rui Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ming ZhouJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Kanger ShenJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ziyi HuangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Qin ZhanDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiayu WangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiaozhe MaoJiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.
Tongguo ShiJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0002-5382-2775
Rui LiJiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.

Funding

Early gastric cancer screening project in Suzhou area P112202420Study on early diagnosis of gastric cancer by plasma miRNA P112204719
6 · The paper itself

Abstract

Confined migration (CM) is a key step in the process of cancer cell metastasis. However, the molecular mechanisms underlying CM in gastric cancer (GC) remain unclear. Here, we found that CM-GC cells had remarkable metastatic and antiapoptotic capacities. Moreover, we observed that HIF-1α was highly expressed in CM-GC cells. HIF-1α knockdown reversed the enhanced metastatic and antiapoptotic capacities of CM-GC cells in vitro and in vivo. Mechanistically, HIF-1α enhanced the metastatic and antiapoptotic capacities of CM-GC cells through phosphatidylcholine (PC) synthesis. Importantly, the addition of L-α-phosphatidylcholine (L-α-PC), a natural PC, markedly increased the metastatic and antiapoptotic capacities of GC cells, similar to CM GC cells. In addition, we observed that increased HIF-1α protein expression was positively correlated with the expression of CEPT1, a key enzyme of PC synthesis, in GC tissue samples. Furthermore, high expression of HIF-1α and CEPT1 in GC tissues predicted poor prognosis in patients with GC. Overall, our study supports the crucial role of HIF-1α in the CM of GC cells and provides novel therapeutic targets and strategies for metastatic GC.

Indexed as

Cell MovementHypoxia-Inducible Factor 1, alpha SubunitPhosphatidylcholinesStomach NeoplasmsAnimalsApoptosisCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeMiddle AgedPrognosisHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitPhosphatidylcholinesCEPT1confined migrationgastric cancerHIF‐1αphosphatidylcholine

Identifiers

PMID40954549
PMCPMC12436174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.