Evidence map›Paper›PMID 40954488›Full record

ArticleThe journal of obstetrics and gynaecology research2025

Doppler abnormality predisposes preterm infants with fetal growth restriction to postnatal intestinal disorder.

Tomohiro Ohtani, Mari Ichinose, Yu Ariyoshi, Miho Irie, Masatake Toshimitsu, Seisuke Sayama, Takahiro Seyama, Hiroshi Muto, Yoshihiko Shitara, Atsushi Ito and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tomohiro OhtaniDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0009-0006-6487-6361
Mari IchinoseDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2974-9109
Yu AriyoshiDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Miho IrieDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Masatake ToshimitsuDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Seisuke SayamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Takahiro SeyamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroshi MutoDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshihiko ShitaraDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Atsushi ItoDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Mariko YoshidaDepartment of Pediatric Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Satsuki KakiuchiDepartment of Neonatal Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Akio IshiguroDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Keiichi KumasawaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Takayuki IriyamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Jun FujishiroDepartment of Pediatric Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Naoto TakahashiDepartment of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yasushi HirotaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yutaka OsugaDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

Japan Society for the Promotion of Science JP22K20935Japan Society for the Promotion of Science JP23K15828
6 · The paper itself

Abstract

objectiveIntestinal disorders (ID) impose a significant burden on preterm infants. Although previous studies have examined individual risk factors for types of ID such as necrotizing enterocolitis (NEC), meconium-related ileus (MRI), and focal intestinal perforation (FIP), the overarching etiology of ID as a whole remains underexplored. Therefore, this study aimed to identify obstetric risk factors for ID.

methodsWe retrospectively investigated singletons without congenital anomalies born between 22 weeks 0 days and 28 weeks 6 days of gestation between January 2013 and December 2022. We compared the frequencies of obstetric factors between patients with ID (ID group) and those without (non-ID group). The obstetric risk factors were maternal background, complications, fetal growth restriction (FGR), chorioamnionitis, Apgar score, and umbilical artery blood gas.

resultsA total of 119 preterm infants were investigated. Of these, 22 (18.5%) had ID, including 14 MRI, 4 FIP, and 5 NEC cases. A total of 33 infants (27.7%) had FGR, which was more common in the ID group (10/22, 45.5% vs. 23/97, 23.7%, p = 0.047). Among patients with FGR, the median time from the onset of Doppler abnormalities in the umbilical artery, middle cerebral artery, or ductus venosus to delivery was significantly longer in patients with ID than in those without (180 h vs. 24 h, p = 0.049).

conclusionFGR was potentially associated with ID in preterm infants. To our knowledge, this is the first study to highlight the impact of prolonged Doppler abnormalities on ID development. These findings suggest that a chronically stressful intrauterine environment may increase postnatal intestinal vulnerability.

Indexed as

Fetal Growth RetardationInfant, Premature, DiseasesIntestinal DiseasesUltrasonography, DopplerAdultEnterocolitis, NecrotizingFemaleHumansInfant, NewbornInfant, PrematureMalePregnancyRetrospective StudiesRisk FactorsUmbilical ArteriesDoppler abnormalityfetal growth restrictionintestinal disordersintrauterine environmentpreterm birth

Identifiers

PMID40954488
PMCPMC12436675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.