Evidence map›Paper›PMID 40954474›Full record

ArticleThyroid research2025

Secondary analyses of swallowing efficiency and safety outcomes following thyroidectomy versus thyroidectomy plus prophylactic central neck dissection.

Molly A Knigge, Daniel Robbins, Susan Thibeault, Nadine Connor, Rebecca Sippel

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02138214 (Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02138214 phase2completednot on this map

Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2014 to 2020Enrolled117ConditionsStage I Papillary Thyroid Cancer, Stage II Papillary Thyroid Cancer, Stage III Papillary Thyroid CancerArmsThyroidectomy, entral lymph node dissection (CLND), Quality-of-life assessment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Molly A KniggeUniversity of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, USA. knigge@surgery.wisc.edu.
Daniel RobbinsDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, USA.
Susan ThibeaultDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, USA.
Nadine ConnorCommunication Sciences and Disorders, Department of Surgery, University of Wisconsin, 1975 Willow Drive, Madison, WI, 53706, USA.
Rebecca SippelDivision of Endocrine Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA.

Funding

Central Neck Dissection in Patients with Clinical Node Negative Thyroid CancerR01CA176911 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P, SIPPEL, REBECCA S · 2014 to 2019
$1.8M
NCI NIH HHS R01 CA176911NIH HHS R01CA176911
6 · The paper itself

Abstract

backgroundSwallowing complaints are common following total thyroidectomy, though an exact mechanism of patient-reported swallowing symptoms following thyroidectomy is currently lacking. This secondary, blinded analysis of data collected in a randomized, controlled clinical trial hypothesized that patients randomly assigned to the central neck dissection group would exhibit increased aspiration and pharyngeal residue on videofluoroscopic swallowing evaluation, and reduced patient-rated swallowing outcomes, as compared to patients randomized to thyroidectomy alone. We further hypothesized that blinded analysis would reveal worse swallowing function two-weeks post-surgery when compared to their pre-operative status to explain qualitative patient-reported dysphagia symptoms.

methodsThirty-two participants randomized to total thyroidectomy treatment with or without central neck dissection underwent pre- and post-surgical evaluation of swallowing outcomes, including videofluoroscopic Penetration/Aspiration Scale ratings, Normalized Residue Ratio Scale measures of valleculae and pyriform sinus residue, and EAT-10 patient-rated outcomes.

resultsNo statistically significant differences were found post-surgery between randomized treatment groups for patient-rated EAT-10 scores (p = 0.2406), penetration/aspiration scale (p = 0.4465) or Normalized Residue Rating Scale scores for either vallecular or pyriform sinus sites. When group data were combined for analysis of differences between pre- and post-operative swallow performance, no statistically significant differences were found in patient-rated EAT-10 scores (p = 0.1374), penetration/aspiration scale (p = 0.7588) or Normalized Residue Rating Scale scores.

conclusionsMeasures of penetration/aspiration and pharyngeal residue failed to substantiate perceptions of post-operative dysphagia reported by patients undergoing total thyroidectomy with or without central neck dissection.

trial registrationClinicalTrials.gov Identifier NCT02138214.

Indexed as

AspirationDysphagiaNeck dissectionThyroidectomy

Identifiers

PMID40954474
PMCPMC12439402

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