Evidence map›Paper›PMID 40954385›Full record

ArticleGeroScience2026

A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration.

Kwangyeon Oh, Dabin Yun, Soyoun Yang, Minju Yuk, Changgyu Lee, Boyoung Kim, Suyeon Heo, Qian Dong, Zhaoming Wang, Hanseul Park and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kwangyeon OhCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Dabin YunCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Soyoun YangCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Minju YukCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Changgyu LeeCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Boyoung KimCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Suyeon HeoCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Qian DongDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhaoming WangDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hanseul ParkCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
Nan SongCollege of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea. nan.song@chungbuk.ac.kr.ORCID http://orcid.org/0000-0002-9182-1060

Funding

Bio & Medical Technology Development Program of the National Research Foundation RS-2024-00440787National Research Foundation of Korea RS-2024-00358322National Research Foundation of Korea RS-2025-02273102
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have been performed on multiple epigenetic clocks to understand the genetic underpinnings of epigenetic age acceleration (EAA). To explore ethnic differences and individual variability in Asian populations, we conducted a GWAS of EAA using multiple epigenetic clocks in the Korean population. Genome-wide single-nucleotide polymorphism (SNP) and methylation data were obtained from 1962 Korean individuals. Five epigenetic clocks (Hannum, DNAm PhenoAge, GrimAge, Zhang2019, and Horvath-Skin&Blood) were considered. GWASs, as well as gene-based, pathway enrichment, quantitative real-time polymerase chain reaction, and quantitative trait loci analyses, were performed to investigate the biological mechanisms. Pleiotropy analyses and drug repurposing were used to explore clinical implications. Six SNPs were independently associated with EAAs (P < 5 × 10

Indexed as

AgingEast Asian PeopleEpigenesis, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyAgedDNA MethylationFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideRepublic of KoreaApoptosisBiological agingDNA methylationEpigenetic age accelerationGenome-wide association studyLiver function

Identifiers

PMID40954385
PMCPMC13356206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.