ArticleGeroScience2026
Post-traumatic stress disorder, depressive symptoms, and cognitive function among middle-aged urban adults: Healthy Aging in Neighborhoods of Diversity across the Life Span study.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Clinical presentation and engagement with a cognitive rehabilitation clinic in individuals reporting anomalous health incidents.Frontiers in neurology · 2026Observational
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Authors and funding
8 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) and depressive symptoms Have been linked to cognitive functioning. However, the impact of PTSD and depression on cognitive functioning, especially among middle-aged urban adults, is not well understood. Cross-sectional data were analyzed from 1434 participants from the Healthy Aging in Neighborhoods of Diversity across the Life Span study. We used multivariable adjusted linear regression and structural equation models (SM) to test the association between PTSD, CES-D, and cognitive test scores. We found PTSD to be strongly associated with depressive symptoms despite adjustment for potential confounders. SM with cognitive test scores as final outcomes found Delayed Free Recall and List A immediate recall inversely associated with PTSD score, with TEs of β ± SE - 0.08398 ± 0.02654, P = 0.002, and β ± SE - 0.10734 ± 0.02571, P < 0.001, respectively, and IEs of β ± SE - 0.06786 ± 0.02202, P = 0.002, and β ± SE - 0.07625 ± 0.02140, P < 0.001, indicating that depressive symptoms significantly mediated the potential association of PTSD with poorer verbal memory. Other cognitive test scores showed significant total or direct effects (p < 0.05), suggesting different pathways not including depressive symptoms as a mediator. At higher intima-media thickness (IMT) tertiles, PTSD score was strongly associated with total CES-D score. This study provides evidence of an association between PTSD and cognitive functioning among middle-aged urban adults, partially mediated through depressive symptoms in verbal memory, with IMT enhancing the association between PTSD and depressive symptoms.
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