Evidence map›Paper›PMID 40954278›Full record

ArticleMolecular psychiatry2025

Oxytocin attenuates the retrieval of methamphetamine-associated reward memories by enhancing adult hippocampal neurogenesis in mice.

Jialing Cai, Xiaohang Che, Yanling Deng, Zhenkun Guo, Meixue Yin, Yuting Li, Xincheng Li, Xiaoling Liu, Yuanchao Luo, Tianyu Xu and 5 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jialing Cai *Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Xiaohang Che *Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.ORCID http://orcid.org/0000-0002-8910-0205
Yanling DengDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Zhenkun GuoDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Meixue YinDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Yuting LiWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Xincheng LiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Xiaoling LiuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Yuanchao LuoDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Tianyu XuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Wenzhe ZhuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Nina AnDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Yijun BaiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Chunfu WuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. wucf@syphu.edu.cn.ORCID http://orcid.org/0000-0003-0316-6076
Jingyu YangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. yangjingyu@syphu.edu.cn.ORCID http://orcid.org/0000-0002-2791-5281

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82204373National Natural Science Foundation of China (National Science Foundation of China) 82273916
6 · The paper itself

Abstract

The present study was designated to investigate the effect of oxytocin (OXT) on the retrieval of methamphetamine (METH)-associated reward memories induced by drugs in mice and its underlying mechanisms related to adult hippocampal neurogenesis (AHN) and memory engrams. The data showed that repeated hippocampal microinjections of OXT (1.25 and 2.5 μg) for 8 consecutive days significantly prevented the retrieval of METH-associated reward memories induced by drugs in a time-, dose- and receptor-dependent manner in mice. At the meanwhile, OXT was found to markedly elevate AHN levels, enhancing the proliferation, survival and maturation of newborn neurons by using NestinCreER

Indexed as

NeurogenesisOxytocinAnimalsDentate GyrusHippocampusMaleMemoryMethamphetamineMiceMice, Inbred C57BLNeuronsRewardMethamphetamineOxytocin

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.