ArticleIntensive care medicine experimental2025
Total liquid ventilation in a porcine model of severe acute respiratory distress syndrome using a new generation of liquid ventilator.
Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Lung volume determines airway stability during total liquid ventilation: evidence from neonatal piglets.Pediatric research · 2026Article
- The impact of head and thorax elevation on respiratory mechanics during cardiopulmonary resuscitation: a multi-model study.Resuscitation plus · 2026Article
- Small Interfering RNA (siRNA) as a Targeted Therapy for Acute Respiratory Distress Syndrome: Evidence from Experimental Models.International journal of molecular sciences · 2026Review
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Authors and funding
18 authors.
Funding
Abstract
backgroundTotal liquid ventilation (TLV) has been experimentally proposed as an alternative treatment for the management of Acute Respiratory Distress Syndrome (ARDS). Recent technological advances have led to the evaluation of a TLV prototype in patients resuscitated after cardiac arrest. Here, our goal was to determine whether a derived version of this prototype, so-called LV4B (liquid ventilation for breathing), could be used for normothermic TLV in a swine model of severe ARDS.
methodsSwine were anesthetized and instrumented for respiratory and hemodynamic evaluation. ARDS was induced by one or two administrations of oleic acid (0.1 mg/kg), until reaching a PaO2/FiO2 ratio < 100 mmHg. After ARDS induction, animals were allocated to undergo 60 min of either gas ventilation continuation (Control group) or TLV using a prototype that continuously controls respiratory rate (RR), liquid tidal volume (LqVt) and end-expiratory liquid volume (EELqV, respectively). Perfluorooctyl bromide was used as breathable liquid.
resultsAfter ARDS induction and group allocation, 2/5 animals (40%) survived in the Control groups versus 5/5 in the TLV group (100%). In the Control group, premature deaths were related to sustained hypoxemia (PaO
conclusionsTLV with a liquid ventilator controlling EELqV, RR and LqVt is feasible and safe in large animals in a severe model of ARDS. This opens promising perspectives and warrants further investigation, including prolonged treatment durations and long-term follow-up.
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