Evidence map›Paper›PMID 40954195›Full record

ArticleCommunications chemistry2025

Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection.

Greta Charlotte Dahm, Usman Akhtar, Alix Bouvier-Müller, Laura Lim, Fabienne Levi-Acobas, Pierre Nicolas Bizat, Germain Niogret, Julian A Tanner, Frédéric Ducongé, Marcel Hollenstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Greta Charlotte DahmInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.ORCID http://orcid.org/0009-0004-4836-891X
Usman AkhtarInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.ORCID http://orcid.org/0000-0002-7124-0656
Alix Bouvier-MüllerInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.
Laura LimInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.
Fabienne Levi-AcobasInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.
Pierre Nicolas BizatInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.ORCID http://orcid.org/0009-0004-1583-6238
Germain NiogretInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.
Julian A TannerSchool of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-5459-1526
Frédéric DucongéCEA, DRF, Institut of biology JACOB, Molecular Imaging Research Center (MIRCen), Université Paris Saclay, CNRS UMR9199, Fontenay aux roses, 92335, France.ORCID http://orcid.org/0000-0002-8595-0050
Marcel HollensteinInstitut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France. marcel.hollenstein@pasteur.fr.ORCID http://orcid.org/0000-0003-0263-9206

Funding

Agence Nationale de la Recherche (French National Research Agency) CNRS/ANR grant PEPR MolecularXiv (ANR-22-PEXM-0002)Institut Pasteur Emergency COVID-19 Fundraising Campaign of Institut Pasteur (project AptaCoV)
6 · The paper itself

Abstract

Decoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes, which often result in improved binding properties. Most functional groups involved in such endeavours mimic the side chains of amino acids or are based on sp

Identifiers

PMID40954195
PMCPMC12436594

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.