Evidence map›Paper›PMID 40954045›Full record

ArticleBMJ open diabetes research & care2025

Slowly progressive type 1 diabetes and female sex as associated factors for pancreatic abnormalities on diagnostic imaging indicating precancerous potential.

Tomoyasu Fukui, Tetsuro Kobayashi, Takuya Awata, Hiroshi Ikegami, Akihisa Imagawa, Yoichi Oikawa, Haruhiko Osawa, Eiji Kawasaki, Masanari Kuwabara, Kazuhiko Kobayashi and 19 more

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Article in BMJ open diabetes research & care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Tomoyasu FukuiDivision of Diabetes, Metabolism and Endocrinology, Department of Medicine, Showa Medical University, Tokyo, Japan showauft@med.showa-u.ac.jp.
Tetsuro KobayashiOkinaka Memorial Institute for Medical Research, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4364-2527
Takuya AwataOkinaka Memorial Institute for Medical Research, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2622-8129
Hiroshi IkegamiDepartment of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka-sayama, Japan.ORCID http://orcid.org/0000-0001-8808-4605
Akihisa ImagawaDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Yoichi OikawaDepartment of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Iruma, Japan.ORCID http://orcid.org/0000-0003-1524-6751
Haruhiko OsawaDepartment of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.
Eiji KawasakiDiabetes, Thyroid and Endocrine Center, Shin-Koga Hospital, Kurume, Japan.ORCID http://orcid.org/0000-0001-7434-4744
Masanari KuwabaraYokoyama Kazuya Cancer Research Institute, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6601-4347
Kazuhiko KobayashiYokoyama Kazuya Cancer Research Institute, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4101-2975
Takeshi KatsukiDepartment of Diabetes and Endocrinology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Norio KanatsunaDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, Takatsuki, Japan.ORCID http://orcid.org/0009-0001-6968-6376
Junji KozawaDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0001-9665-8947
Noriko KodaniDepartment of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4443-1545
Akira ShimadaDepartment of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Iruma, Japan.ORCID http://orcid.org/0000-0002-3954-4983
Masayuki ShimodaDepartment of Pancreatic Islet Cell Transplantation, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0338-0008
Kazuma TakahashiIwate Prefectural University, Takizawa, Japan.ORCID http://orcid.org/0009-0005-1655-7094
Daisuke ChujoDepartment of Diabetes, Metabolism, and Endocrinology, International University of Health and Welfare, Ichikawa, Japan.ORCID http://orcid.org/0000-0001-7727-6310
Tetsuro TsujimotoDepartment of Diabetes and Endocrinology, Toranomon Hospital Kajigaya, Kawasaki, Japan.
Kyoichiro TsuchiyaFaculty of Medicine, Department of Diabetes and Endocrinology, Graduate School of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Jungo TerasakiDepartment of Internal Medicine (I), Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Kan NagasawaIwate Medical University, Shiwa, Japan.ORCID http://orcid.org/0009-0002-3815-1173
Shinsuke NosoDepartment of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka-sayama, Japan.ORCID http://orcid.org/0000-0002-0943-8450
Ichiro HorieDepartment of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki, Japan.ORCID http://orcid.org/0000-0003-3430-5796
Kazuki YasudaDepartment of Diabetes, Endocrinology, and Metabolism, Kyorin University, Mitaka, Japan.ORCID http://orcid.org/0000-0002-6966-496X
Hisafumi YasudaDepartment of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan.ORCID http://orcid.org/0000-0003-3742-9268
Toshiaki HanafusaSakai City Medical Center, Sakai, Japan.ORCID http://orcid.org/0000-0001-7482-6823
Hiroshi KajioDepartment of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Japanese Type 1 Diabetes Database Study (TIDE-J)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to identify factors associated with pancreatic abnormal findings on imaging (PAI) suggesting precancerous potential between slowly progressive type 1 diabetes and acute-onset type 1 diabetes. RESEARCH DESIGN AND

methodsThe study was designed to identify factors associated with PAI using data from a nationwide cohort, the Japanese Type 1 Diabetes Database. Clinical factors, including sex, age, type of diabetes onset, diabetes duration, body mass index, and human leucocyte antigen genotypes associated with type 1 diabetes, were evaluated.

resultsAmong 279 patients with type 1 diabetes, 95 patients who had not undergone imaging evaluations, two patients with pancreatic lipomatosis, and 15 patients with missing data were excluded. Finally, a total of 167 patients with type 1 diabetes were analyzed. Among 13 patients who were identified as PAI positive, female sex (92.3% vs 53.2%, p=0.007), slowly progressive type 1 diabetes (69.2% vs 36.4%, p=0.034), and older age were more common compared with PAI-negative cases. The multivariable logistic regression analysis revealed that female sex (OR 13.87; 95% CI 1.6 to 120.1; p=0.017), slowly progressive type 1 diabetes (OR 5.70; 95% CI 1.46 to 22.19; p=0.012), and age (OR 1.05; 95% CI 1.002 to 1.103; p=0.043) were independently associated with PAI positivity.

conclusionsThe findings indicate that slowly progressive type 1 diabetes and female sex are closely associated with PAI, along with age. These results suggest the need for increased clinical vigilance for pancreatic pathology in patients with slowly progressive type 1 diabetes.

Indexed as

Diabetes Mellitus, Type 1Diagnostic ImagingPancreasPancreatic NeoplasmsPrecancerous ConditionsAdolescentAdultChildDisease ProgressionFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedPrognosisDiabetes Mellitus, Type 1Pancreas

Identifiers

PMID40954045
PMCPMC12439140

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