Evidence map›Paper›PMID 40954032›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking.

Valentina Martinez Damonte, Lydia G Bailey, Amit Thakar, Joanna Stralka, Travis E Brown, Julie A Kauer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Valentina Martinez DamonteDepartment of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305.ORCID 0000-0003-2843-2414
Lydia G BaileyDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163.
Amit ThakarDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163.
Joanna StralkaDepartment of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305.
Travis E BrownDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99163.
Julie A KauerDepartment of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Stanford, California 94305 jkauer@stanford.edu.ORCID 0000-0002-3362-1642

Funding

Inhibitory Synaptic Transmission, Stress and Drugs of AbuseR01DA011289 · NIDA · STANFORD UNIVERSITY · PI KAUER, JULIE A. · 1997 to 2023
$6.8M
Cocaine, Parvalbumin, and Perineuronal NetsR01DA055645 · NIDA · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI SUE A AICHER, Travis Eugene Brown · 2023 to 2026
$2.9M
NIDA NIH HHS R01 DA011289NIDA NIH HHS R01 DA055645
6 · The paper itself

Abstract

Stress is a potent trigger for drug-seeking behaviors in both rodents and humans with a history of substance use. Kappa opioid receptors (kORs) play a critical role in mediating stress responses. Our previous studies in the ventral tegmental area (VTA) demonstrated that acute stress activates kORs to block long-term potentiation at GABA

Indexed as

CocaineCocaine-Related DisordersDrug-Seeking BehaviorReceptors, Opioid, kappaStress, PsychologicalVentral Tegmental AreaAnimalsDopaminergic NeuronsFemaleGABAergic NeuronsLong-Term PotentiationMaleMiceMice, Inbred C57BLMice, KnockoutNeural PathwaysCocaineReceptors, Opioid, kappaLTPnucleus accumbensoptogeneticsplasticityself-administrationventral tegmental area

Identifiers

PMID40954032
PMCPMC12548717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.