Evidence map›Paper›PMID 40954016›Full record

ArticleGenes & development2025

Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations.

Raúl Sánchez-Vázquez, Sonia Burgaz García-Oteyza, Rosa Serrano, Juana M Flores, Paula Martínez, Maria A Blasco

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raúl Sánchez-VázquezTelomeres and Telomerase Group, Molecular Oncology Program, Spanish National Research Cancer Centre (CNIO), Madrid E-28029, Spain.
Sonia Burgaz García-OteyzaTelomeres and Telomerase Group, Molecular Oncology Program, Spanish National Research Cancer Centre (CNIO), Madrid E-28029, Spain.
Rosa SerranoTelomeres and Telomerase Group, Molecular Oncology Program, Spanish National Research Cancer Centre (CNIO), Madrid E-28029, Spain.
Juana M FloresAnimal Surgery and Medicine Department, Faculty of Veterinary Science, Complutense University of Madrid, Madrid E-28040, Spain.
Paula MartínezTelomeres and Telomerase Group, Molecular Oncology Program, Spanish National Research Cancer Centre (CNIO), Madrid E-28029, Spain; mblasco@cnio.es pmartinez@cnio.es.
Maria A BlascoTelomeres and Telomerase Group, Molecular Oncology Program, Spanish National Research Cancer Centre (CNIO), Madrid E-28029, Spain; mblasco@cnio.es pmartinez@cnio.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary fibrosis is a lethal disease associated with damaging insults to the lung and with organismal aging. The presence of short and dysfunctional telomeres has been placed at the origin of this disease in a percentage of both familial and sporadic cases. Recently, a mutation in the telomere-binding protein

Indexed as

Pulmonary FibrosisTelomeraseTelomere-Binding ProteinsTelomere ShorteningAnimalsDisease Models, AnimalFemaleGene Knock-In TechniquesHumansLungMaleMiceMutationPhenotypeShelterin ComplexTelomereACD protein, humanAcd protein, mousePOT1 protein, humanPOT1 protein, mouseShelterin ComplexTelomeraseTelomere-Binding Proteinsagingpulmonary fibrosisshelterintelomeres

Identifiers

PMID40954016
PMCPMC12667383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.