Evidence map›Paper›PMID 40953924›Full record

ArticleStroke and vascular neurology2026

BEST-BAO: a multicentre, prospective, randomised controlled trial of endovascular treatment with or without intravenous thrombolysis in acute ischaemic stroke due to basilar artery occlusion - study protocol and rationale.

Yang Xiang, Shu Yang, Lei Guo, Chongya Dong, Charles B L M Majoie, Adnan H Siddiqui, J Mocco, Fabiano Cavalcante, Bing-Hu Li, Jian-Hong Wang and 6 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke and vascular neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05631847 (Endovascular Treatment With Or Without Intravenous Alteplase In Acute Ischemic Stroke Of Basilar Artery Occlusion), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05631847 nacompletednot on this map

Endovascular Treatment With Or Without Intravenous Alteplase In Acute Ischemic Stroke Of Basilar Artery Occlusion: A Multicenter, Prospective, Randomized Controlled Trial (BEST-BAO)

TypeinterventionalSponsorSichuan Academy of Medical SciencesRan2023 to 2025Enrolled345ConditionsAcute Ischemic Stroke, Basilar Artery Occlusion, Thrombosis, AlteplaseArmsEndovascular treatment, Intravenous thrombolysis (Alteplase)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yang Xiang *Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-6971-0356
Shu Yang *Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Lei GuoDepartment of Neurology, Xindu District People's Hospital of Chengdu, Chengdu, Sichuan, China.
Chongya DongClinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, Beijing, China.
Charles B L M MajoieDepartment of Radiology, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Adnan H SiddiquiDepartment of Neurosurgery and Radiology and Canon Stroke and Vascular Research Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
J MoccoDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Health System, New York, NY, USA.ORCID http://orcid.org/0000-0001-5489-2524
Fabiano CavalcanteDepartment of Radiology, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Bing-Hu LiDepartment of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-1925-5535
Jian-Hong WangDepartment of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Bin HuangDepartment of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Duo-Zi WangDepartment of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Neng-Wei YuDepartment of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China guofuqiang2005@126.com 18981838652@126.com w.schonewille@antoniusziekenhuis.nl aturk@ghs.org.ORCID http://orcid.org/0000-0001-8761-7449
Wouter J SchonewilleDepartment of Neurology, Saint Antonius Hospital, Nieuwegein, The Netherlands guofuqiang2005@126.com 18981838652@126.com w.schonewille@antoniusziekenhuis.nl aturk@ghs.org.
Aquilla S TurkDepartment of Neurosurgery, Prisma Health Upstate, Greenville, South Carolina, USA guofuqiang2005@126.com 18981838652@126.com w.schonewille@antoniusziekenhuis.nl aturk@ghs.org.
Fu-Qiang GuoDepartment of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China guofuqiang2005@126.com 18981838652@126.com w.schonewille@antoniusziekenhuis.nl aturk@ghs.org.ORCID http://orcid.org/0000-0002-0665-4414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndovascular treatment (EVT) is safe and effective in treating acute ischaemic stroke due to basilar artery occlusion (AIS-BAO); nonetheless, the impact of intravenous thrombolysis (IVT) on its efficacy remains unclear.

objectiveTo compare the effectiveness and safety of EVT with or without prior IVT in treating AIS-BAO patients within 4.5 hours after stroke onset. METHODS AND

designA multicentre, prospective, randomised, open-label controlled clinical trial with blinded assessment of endpoints. 340 patients will be consecutively randomised to receive IVT plus EVT or direct EVT in a ratio of 1:1 from about 100 hospitals in China. An interim analysis is planned when one-third (114) of the patients have completed the primary endpoint follow-ups. It anticipates that IVT plus EVT demonstrates superiority over direct EVT. If the superiority of IVT plus EVT over direct EVT is less than expected, the sample size may be expanded by up to 20% of the original size. If the efficacy of the two groups is similar, it will shift to a non-inferiority hypothesis, aiming to evaluate whether direct EVT is non-inferior to IVT plus EVT. OUTCOME: The primary endpoint is the proportion of independent neurological function defined as a modified Rankin Scale score of 0 to 2 at 90±14 days after stroke onset. DISCUSSION: This trial is expected to provide novel evidence of the superiority or non-inferiority between EVT with or without IVT in the treatment of patients with AIS-BAO.

trial registrationNCT05631847 at ClinicalTrials.gov and ChiCTR2300070584 at Chictr.org.cn.

Indexed as

Endovascular ProceduresFibrinolytic AgentsIschemic StrokeThrombolytic TherapyVertebrobasilar InsufficiencyAdministration, IntravenousChinaClinical ProtocolsEquivalence Trials as TopicHumansMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicRecovery of FunctionResearch DesignTime FactorsFibrinolytic AgentsInterventionIschaemic StrokeThrombectomy

Identifiers

PMID40953924
PMCPMC13347895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.