Evidence map›Paper›PMID 40953912›Full record

Observational studyLupus science & medicine2025

Prevalence and determinants of vertebral fractures in a SLE cohort.

Denise Rotta, Giovanni Adami, Isotta Galvagni, Francesca Pistillo, Angelo Fassio, Davide Gatti, Margherita Zen, Viviana Ravagnani, Federica Maiolini, Jacopo Croce and 7 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Lupus science & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05590390 (Prevalence and Impact on Quality of Life of Osteoporosis and Fragility Fractures Among SLE Patients.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05590390 active not recruitingnot on this map

Prevalence and Impact on Quality of Life of Osteoporosis and Fragility Fractures Among SLE Patients. (FRAIL Trial)

TypeobservationalSponsorAzienda Ospedaliera Universitaria Integrata VeronaRan2022 to 2024Enrolled300ConditionsLupus Erythematosus, SystemicArmsDXA, serum sample, PROs
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Denise RottaRheumatology Unit, University of Verona, Verona, Italy denise.rotta.dr@gmail.com.ORCID 0000-0002-1946-2438
Giovanni AdamiRheumatology Unit, University of Verona, Verona, Italy.
Isotta GalvagniRheumatology Unit, University of Verona, Verona, Italy.
Francesca PistilloRheumatology Unit, University of Verona, Verona, Italy.
Angelo FassioRheumatology Unit, University of Verona, Verona, Italy.
Davide GattiRheumatology Unit, University of Verona, Verona, Italy.
Margherita ZenDepartment of Medicine DIMED, University of Padua, Padua, Italy.
Viviana RavagnaniRheumatology Unit, Trento, Italy.
Federica MaioliniDepartment of Internal Medicine, University of Verona, Verona, Italy.
Jacopo CroceDepartment of Internal Medicine, University of Verona, Verona, Italy.
Alessandro VolpeRheumatology Unit, Sacro Cuore Don Calabria Hospital, Verona, Italy.
Carmela DartizioRheumatology Unit, University of Verona, Verona, Italy.
Camilla BeniniRheumatology Unit, University of Verona, Verona, Italy.
Francesca RuzzonRheumatology Unit, University of Verona, Verona, Italy.
Ombretta ViapianaRheumatology Unit, University of Verona, Verona, Italy.
Maurizio RossiniRheumatology Unit, University of Verona, Verona, Italy.
Giovanni OrsoliniRheumatology Unit, University of Verona, Verona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by multiorgan involvement. Osteoporosis and fragility fractures, particularly vertebral fractures, are significant, yet often underestimated, comorbidities in patients with SLE. This study aims to evaluate the prevalence of vertebral fractures and their associations with demographic, disease-related and therapy-related factors in patients with SLE.

methodsWe conducted a monocentric, cross-sectional study to systematically evaluate bone health using dual-energy X-ray absorptiometry and vertebral fracture assessment (VFA). Associations between vertebral fractures and clinical, laboratory variables were investigated with logistic and linear regressions.

resultsOne hundred and six patients with SLE were included. The overall prevalence of radiographic vertebral fractures was 21.7%, whereas clinical vertebral fractures were reported in 14.2% of patients. New, previously not diagnosed, radiographic vertebral fractures were detected in 14.2% of all patients with SLE at screening with VFA. Older age, longer disease duration, cumulative glucocorticoid (GC) dose and lower bone mineral density were significantly associated with vertebral fractures. Cumulative GC dose had the strongest association with vertebral fractures. We also found a positive association between the number of vertebral fractures on VFA and cumulative GC dose (β 0.025, p=0.025).

conclusionsOur findings underscore the importance of actively screening for vertebral fractures in patients with SLE, especially those on long-term GC therapy, to prevent underdiagnosis, mitigate the risk of further skeletal damage and facilitate the timely initiation of targeted antiosteoporotic treatments when indicated. TRIAL REGISTRATION NUMBER: NCT05590390.

Indexed as

Lupus Erythematosus, SystemicOsteoporosisSpinal FracturesAbsorptiometry, PhotonAdultAgedBone DensityCross-Sectional StudiesFemaleGlucocorticoidsHumansMaleMiddle AgedPrevalenceRisk FactorsGlucocorticoidsBone DensityGlucocorticoidsLupus Erythematosus, SystemicOsteoporosis

Identifiers

PMID40953912
PMCPMC12434772

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.