ArticleRapid communications in mass spectrometry : RCM2025
A Pilot Study Using Microbial Glycolipid Signatures to Diagnose Nosocomial Ventriculitis.
Article in Rapid communications in mass spectrometry : RCM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Pilot Study Using Microbial Glycolipid Signatures to Diagnose Nosocomial Ventriculitis.Rapid communications in mass spectrometry : RCM · 2025Article
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4 authors.
Funding
Abstract
rationaleVentriculitis is a life-threatening infectious condition that requires rapid pathogen identification. Conventional diagnostic methods often require 24-48 h of ex vivo culture. The aim of this study was to evaluate a novel MALDI-TOF MS approach for analyzing glycolipids for species-level pathogen identification directly from cerebral spinal fluid (CSF).
methodsPathogen identification was conducted with the fast lipid analysis technique (FLAT), combined with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). In this pilot study, 12 CSF samples were analyzed, comprising six culture-positive and six true negative specimens. The FLAT method was applied to 1 mL of CSF from each sample, enabling pathogen identification within approximately 1.5 h.
resultsFLAT was performed directly on CSF in under 2 h. Successful genus-level identification for all six culture-positive samples was achieved, with five out of six correctly identified at the species level. Importantly, culture-negative samples did not produce any pathogen-associated glycolipid fingerprints, indicating the method's specificity.
conclusionThis study highlights the potential of FLAT followed by MALDI-TOF MS as a valuable tool for expediting ventriculitis pathogen identification. By bypassing the need for culture and delivering results in about an hour, this approach could significantly reduce turnaround times and potentially improve patient outcomes.
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