Evidence map›Paper›PMID 40953822›Full record

ArticleJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2026

The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.

Leong-Perng Chan, Ya-Ping Tseng, Hui-Ching Wang, Chen-Yu Chien, Che-Wei Wu, Ling-Feng Wang, Tung-Wen Yen, Po-Chun Wang, Chih-Chuang Liaw, Chia-Hua Liang

Abstract read
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In one paragraph

Article in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leong-Perng ChanDepartment of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ya-Ping TsengInstitute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.
Hui-Ching WangDepartment of Internal Medicine, Division of Hematology and Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chen-Yu ChienDepartment of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Che-Wei WuDepartment of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-1052-5348
Ling-Feng WangDepartment of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Tung-Wen YenDepartment of Cosmetic Science and Institute of Cosmetic Science, Chia nan University of Pharmacy and Science, Tainan, Taiwan.
Po-Chun WangDepartment of Food and Drug Industry and Inspective Technology, Chia nan University of Pharmacy and Science, Tainan, Taiwan.
Chih-Chuang LiawDepartment of Marine Biotechnology and Resources, National sun Yat-Sen University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-3552-3958
Chia-Hua LiangDepartment of Cosmetic Science and Institute of Cosmetic Science, Chia nan University of Pharmacy and Science, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-8589-4805

Funding

Ministry of Science and Technology NSTC113-2314-B-037-034Ministry of Science and Technology NSTC113-2320-B-041-001-MY3
6 · The paper itself

Abstract

background16-hydroxycleroda-3,13-dien-15,16-olide (HCD), a compound isolated from Polyalthia longifolia var. pendula, has been identified as a PI3K inhibitor. P. longifolia var. pendula is recognized for its diverse pharmacological properties, including antimicrobial, hypotensive, anti-inflammatory, and cytotoxic activities. Considering the pivotal role of PI3K in the regulation of apoptosis in cancer cells, this study aims to investigate the apoptotic effects induced by HCD in head and neck cancer cell models.

methodsThe study focused on investigating the mechanism through which HCD induces apoptosis in oral squamous cell carcinoma (OSCC) using SCC25 and SCC180 cells. These cells were treated with HCD at IC

resultsThe results demonstrated that HCD significantly increased the sub-G

conclusionThis investigation into HCD's molecular mechanisms in OSCC cells offers insight into developing effective anticancer therapies, highlighting its role in apoptosis induction through oxidative stress, mitochondrial pathways, and death receptor signaling.

Indexed as

ApoptosisCarcinoma, Squamous CellCaspasesHead and Neck NeoplasmsPhosphoinositide-3 Kinase InhibitorsCaspase 3Cell Line, TumorCell SurvivalCytochromes cEnzyme ActivationHumansOxidative StressReactive Oxygen SpeciesSignal TransductionSquamous Cell Carcinoma of Head and NeckUp-RegulationCaspase 3CaspasesCytochromes cPhosphoinositide-3 Kinase InhibitorsReactive Oxygen Species16‐hydroxycleroda‐3,13‐dien‐15,16‐olidedeath domainhuman oral squamous cell carcinomamitochondrial pathwayPI3K inhibitor

Identifiers

PMID40953822
PMCPMC12774572

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.