Evidence map›Paper›PMID 40953762›Full record

ReviewThe journal of pain2025

Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.

John K Neubert, Kyle Allen, Tamara Alliston, Alejandro J Almarza, Kyriacos A Athanasiou, Basak Donertas-Ayaz, Bruna Balbino de Paula, Roxanne Bavarian, Nidhi Bhutani, Brian E Cairns and 28 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

John K NeubertDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA; McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA. Electronic address: jneubert@tamu.edu.
Kyle AllenDepartment of Biomedical Engineering, University of Florida, Gainesville, FL 32610, USA.
Tamara AllistonDepartment of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
Alejandro J AlmarzaDepartment of Oral and Craniofacial Sciences, Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Basak Donertas-AyazDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
Bruna Balbino de PaulaDepartment of Oral & Maxillofacial Surgery, University of Florida, Gainesville, FL 32610, USA.
Roxanne BavarianDepartment of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
Nidhi BhutaniDepartment of Orthopaedic Surgery, Stanford University, Palo Alto, CA, USA.
Brian E CairnsFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Robert M CaudleDepartment of Oral & Maxillofacial Surgery, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA.
Yang ChaiCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, USA.
Jian-Fu ChenCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, USA.
Yong ChenDepartments of Neurology, Anesthesiology, and Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
Glenn T ClarkCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, USA.
Yenisel Cruz-AlmeidaDepartment of Community Dentistry & Behavioral Science, University of Florida, Gainesville, FL, USA.
Alexandre F DaSilvaDepartment of Biologic & Materials Sciences, University of Michigan, Ann Arbor, MI, USA.
Paul L DurhamDepartment of Biology, Missouri State University, Springfield, MO 65806, USA.
Airam Vivanco EstelaDepartment of Oral & Maxillofacial Surgery, University of Florida, Gainesville, FL 32610, USA.
Millie EmbreeDepartment of Orthodontics, Columbia University, New York, NY, USA.
Roger FillingimDepartment of Community Dentistry & Behavioral Science, University of Florida, Gainesville, FL, USA.
Fernando GuastaldiDepartment of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
Shruti HandaDepartment of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
Sunil D KapilaDepartment of Orthodontics, University of California Los Angeles, Los Angeles, CA, USA.
David KeithDepartment of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
Keith L KirkwoodDepartment of Oral Biology, University at Buffalo, Buffalo, NY, USA.
Phillip KramerDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
Katherine T MartucciCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Niall P MurphyDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
Andrea G NackleyCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Richard OhrbachDepartment of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA.
Benedikt SaglUniversity Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Shad B SmithCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Feng TaoDepartment of Biomedical Sciences, College of Dentistry, Texas A&M University, Dallas, TX, USA.
Beth WinkelsteinDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Hai YaoDepartment of Bioengineering, Clemson University, USA.
Simon YoungDepartment of Oral Maxillofacial Surgery, University of Texas Houston, Houston, TX, USA.
Michael S GoldDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Project 1U54DE035413 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yenisel Cruz-Almeida · 2025 to 2026
$9.9M
The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
The mechanistic control of bone quality and joint crosstalk by osteocytesR01DE019284 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, CHRISTOPHER JOHN · 2009 to 2024
$7.6M
Identification and validation of LPA/LPAR signaling as a target for the treatment of temporomandibular disorder painR01DE032676 · NIDCR · DUKE UNIVERSITY · PI CHEN, YONG, NACKLEY, ANDREA G · 2024 to 2024
$2.4M
TMJ SYMPHONY Systems-integrated model and mechanisms of patient-centered holistic outcomes and network-supported training and therapyR34DE033593 · NIDCR · CLEMSON UNIVERSITY · PI YAO, HAI · 2023 to 2023
$384k
Traumatic Events and Injury: Etiologic Mechanisms for Temporomandibular DisordersR34DE033592 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KIRKWOOD, KEITH L, OHRBACH, RICHARD · 2023 to 2023
$339k
PUFA metabolism for prevention and treatment of TMD pain: an interdisciplinary, translational approach.R34DE033563 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANDERS, ANNE E., SLADE, GARY DOUGLAS · 2023 to 2023
$315k
Interdisciplinary Clinical Advances and Research Excellence in TMDs (ICARE 4 TMDs) CollaborativeR34DE033595 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAPILA, SUNIL D · 2023 to 2023
$312k
Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR)R34DE033630 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE, KOHN, DAVID H. · 2023 to 2023
$312k
Collaborative for REsearch to Advance TMD Evidence (CREATE)R34DE033591 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALMARZA, ALEJANDRO JOSE, FILLINGIM, ROGER B · 2023 to 2023
$272k
NIBIB NIH HHS P41 EB031772NIDCR NIH HHS R01 DE019284NIDCR NIH HHS R01 DE032676NIDCR NIH HHS R34 DE033563NIDCR NIH HHS R34 DE033591NIDCR NIH HHS R34 DE033592NIDCR NIH HHS R34 DE033593NIDCR NIH HHS R34 DE033595NIDCR NIH HHS R34 DE033630NIDCR NIH HHS U54 DE035413
6 · The paper itself

Abstract

Temporomandibular disorders (TMDs) are complex conditions characterized by orofacial pain and dysfunction, affecting a significant portion of the population. TMDs may involve joint and/or muscle pain, dysfunction (e.g., noise, limited or altered jaw movements), or both, leading to a marked decrease in quality of life. Patients often experience functional limitations that hinder eating, speaking, and daily activities. Additionally, TMDs are frequently associated with psychological distress, including anxiety and depression, which further impacts overall well-being. Despite the profound individual and societal impact of TMDs, effective therapies remain elusive, partly due to deficiencies in translational research. A primary limitation in the TMD field is the scarcity of animal models that accurately replicate disease features in humans. This may ultimately be due to species differences, but likely also reflects the etiological and symptomatic heterogeneities of TMDs, as there are over 30 different conditions in this umbrella term. Both factors pose a significant challenge in developing and using animal models for TMD research. This review highlights preclinical TMD research to enhance clinical care, focusing on anatomy/physiology, pain and behavior models, functional and tissue modeling, biopsychosocial factors, and technological considerations. The "TMD Research Community" collaborated to produce this review, with the Discussion offering a proposal for a path forward.

Indexed as

Disease Models, AnimalFacial PainTemporomandibular Joint DisordersAnimalsHumansBiomechanicsBiopsychosocial modelOrofacial painPreclinical modelsTemporomandibular disorder (TMD)

Identifiers

PMID40953762
PMCPMC12677152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.