Evidence map›Paper›PMID 40953265›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Circadian-informed modeling predicts regional variation in obesity and stroke outcomes under different permanent US time policies.

Lara Weed, Jamie M Zeitzer

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Challenges of county-level circadian modeling for time-policy debates.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. The sum of absolute circadian shifts: Questioning the metric linking daylight saving time policy to stroke and obesity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Health-Framed Messaging and Its Impact on Attitudes Toward Daylight Saving Time.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lara WeedDepartment of Bioengineering, Schools of Engineering and Medicine, Stanford University, Stanford, CA 94305.
Jamie M ZeitzerDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305.ORCID 0000-0001-6174-5282

Funding

A quantitative framework for measuring the coordination of central and peripheral body clocks in humans in the real worldF31HL170715 · NHLBI · STANFORD UNIVERSITY · PI WEED, LARA · 2024 to 2025
$99k
NHLBI NIH HHS F31 HL170715NHLBI NIH HHS F31HL170715
6 · The paper itself

Abstract

Seasonal changes in time policy, such as switching between Standard Time (SDT) and Daylight Saving Time (DST), have been adopted by many countries, including the United States. While transitioning between SDT and DST has notable acute negative population health impacts, the chronic impact of these time policies on health has not been well evaluated. To estimate the impact of permanent SDT or DST on health, we modeled the circadian impact of SDT, DST, and Biannual Shifting (BAS) across a year in the contiguous, continental United States. We find that BAS produces a greater burden on the circadian system as compared to either permanent SDT or DST. Chronotype as well as location (latitude and location within time zones) impact this burden. Analyzing these data relative to county-level health data (Centers for Disease Control and Prevention Places dataset), we find that, under idealized light exposure conditions and after controlling for health and socioeconomic factors, there would be a decrease in the prevalence of both obesity [[Formula: see text]0.78% ([Formula: see text]0.06% to [Formula: see text]1.49%)] and stroke [[Formula: see text]0.09% ([Formula: see text]0.04% to [Formula: see text]0.14%)] under SDT compared with the current policy. The prevalence of both obesity [[Formula: see text]0.51% ([Formula: see text]0.09% to [Formula: see text]0.93%)] and stroke [[Formula: see text]0.07% ([Formula: see text]0.04% to [Formula: see text]0.09%)] would also decrease under permanent DST, though to a lesser degree. Our data, reflecting the impact of time policy on circadian burden and subsequent health benefits, support the cessation of BAS.

Indexed as

Circadian RhythmObesityStrokeHumansSeasonsTime FactorsUnited Statescircadian rhythmshealthlightmathematical modelssleep

Identifiers

PMID40953265
PMCPMC12478180

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.