ArticleJournal of neurophysiology2025
Phrenic long-term facilitation following severe acute intermittent hypoxia is preserved in geriatric male rats.
Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sympathetic long-term facilitation following acute intermittent hypoxia is similar in the diurnal rest versus active phase in vagal-intact rats.Journal of neurophysiology · 2026Article
- Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats.Function (Oxford, England) · 2026Article
- Vagal suppression of diurnal variations in acute intermittent hypoxia-induced phrenic long-term facilitation.Journal of neurophysiology · 2026Article
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Abstract
Acute intermittent hypoxia (AIH) elicits a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). Although AIH comprised of moderate versus severe hypoxic episodes both elicit pLTF, they do so via completely distinct cellular mechanisms. In young adult male rats, moderate AIH (mAIH) elicits pLTF via a serotonin-driven, adenosine-constrained mechanism. In aged rats, mAIH-induced pLTF is diminished due to increased basal spinal adenosine levels that further constrain serotonin-driven pLTF. In contrast, in young male rats, severe AIH (sAIH) elicits pLTF via an adenosine-dominant, serotonin-constrained mechanism. Since basal spinal adenosine levels are elevated in aged male rats, we tested the hypothesis that adenosine-dependent, sAIH-induced pLTF is enhanced in aged versus young male rats. Young (∼3 mo) and aged (∼20 mo) male Sprague-Dawley rats were urethane-anesthetized, ventilated, vagotomized, paralyzed, and exposed to sAIH (3, 5-min episodes, arterial Po
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