Evidence map›Paper›PMID 40953110›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Impaired parasympathetic network function confers susceptibility to neurodegeneration and memory impairment in older adults with elevated beat-to-beat blood pressure variability.

Trevor Lohman, Isabel Sible, Arunima Kapoor, Allison C Engstrom, Fatemah Shenasa, John Paul M Alitin, Aimee Gaubert, Kathleen E Rodgers, David Bradford, Mara Mather and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Trevor LohmanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9634-702X
Isabel SibleDepartment of Neurology, University of California, San Francisco, CA, USA.
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, CA, USA.
Allison C EngstromDepartment of Psychological Science, University of California, Irvine, CA, USA.
Fatemah ShenasaDepartment of Psychological Science, University of California, Irvine, CA, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Aimee GaubertLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kathleen E RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
David BradfordCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Mara MatherLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
S Duke HanDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Lorena SordoDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Julian F ThayerDepartment of Psychological Science, University of California, Irvine, CA, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9123-0658

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073
6 · The paper itself

Abstract

BackgroundBlood pressure variability (BPV) is associated with neurodegeneration and cognitive decline independent of average pressure. The effect of parasympathetic central autonomic network (CAN) impairment on this relationship has not been assessed.ObjectiveDetermine whether parasympathetic CAN network function affects the relationship between BPV and neurodegenerative markers.Methods100 independently living older adults (55-89 years) underwent continuous blood pressure monitoring, neuropsychological testing, venipuncture, and brain MRI. Hippocampal volumes and entorhinal cortex thicknesses were assessed. Functional connectivity within a parasympathetic cardiovascular control network was used as a measure of parasympathetic CAN function. Plasma glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) were used as measures of glial and neuronal injury, respectively.ResultsElevated BPV was associated with left hippocampal atrophy (p

Indexed as

Blood PressureMemory DisordersNeurodegenerative DiseasesParasympathetic Nervous SystemAgedAged, 80 and overFemaleGlial Fibrillary Acidic ProteinHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeurofilament ProteinsNeuropsychological TestsGlial Fibrillary Acidic ProteinNeurofilament ProteinsAlzheimer's diseaseblood pressure variabilitycentral autonomic networkglial fibrillary acidic proteinneurodegenerationneurofilament light chainparasympathetic

Identifiers

PMID40953110
PMCPMC12927715

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.