Evidence map›Paper›PMID 40953069›Full record

ReviewPLoS neglected tropical diseases2025

Unexplained subcutaneous swelling: Keep echinococcosis in mind! Report of two primary extrahepatic subcutaneous echinococcosis cases and literature review.

Louis Bohard, Eléonore Brumpt, Noémie Tissot, Marie Lacoste, Olivia Chapuis, Sophie Felix, Jenny Knapp, Carole Hartmann-Gouvenot, Yannick Jeffredo, Frederic Grenouillet and 4 more

Abstract readCase ReportsReview
In one paragraph

Review in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Louis BohardInfectious Diseases Department, Jean Minjoz University Hospital Besançon, Besançon, France.
Eléonore BrumptVisceral Radiology Department, Jean Minjoz University Hospital, Besançon, France.
Noémie TissotInfectious Diseases Department, Jean Minjoz University Hospital Besançon, Besançon, France.
Marie LacosteInfectious Diseases Unit, Alpes-Léman Hospital, Contamine/Arve, France.
Olivia ChapuisPrivate Pathology Laboratory, Argonay, France.
Sophie FelixPathology Laboratory, Jean Minjoz University Hospital, Besançon, France.
Jenny KnappUMR CNRS Chrono environment laboratory, Marie et Louis Pasteur University, Besançon, France.
Carole Hartmann-GouvenotPrivate General Medicine Office, Belfort, France.
Yannick JeffredoPrivate Pathology Laboratory, Belfort , France.
Frederic GrenouilletUMR CNRS Chrono environment laboratory, Marie et Louis Pasteur University, Besançon, France.
Damien MontangeClinical Pharmacology Laboratory, Jean Minjoz University Hospital, Besançon, France.
Anne-Pauline BellangerUMR CNRS Chrono environment laboratory, Marie et Louis Pasteur University, Besançon, France.
Catherine ChirouzeInfectious Diseases Department, Jean Minjoz University Hospital Besançon, Besançon, France.
Solange Bresson-HadniUMR CNRS Chrono environment laboratory, Marie et Louis Pasteur University, Besançon, France.ORCID 0000-0003-1258-4050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar and cystic echinococcoses (AE and CE) are parasitic zoonoses, mainly affecting the liver. Primary extrahepatic localizations remain rare and are difficult to diagnose. We report two cases of primary subcutaneous echinococcosis and the largest literature review on the subject. The first case is an alveolar echinococcosis located in the forehead region and the second a cystic echinococcosis in the abdominal wall. To our knowledge, a primary AE location in the face has never been described before. Pre-surgical diagnosis was not made in these two cases. However, it is essential to apply specific measures, depending on the type of echinococcosis (AE or CE), to prevent parasitic dissemination and recurrence. In view of the cases presented here, prolonged albendazole can be a second-line alternative to a surgical strategy. Echinococcosis should be kept in mind for differential diagnosis of soft tissue lesions in any part of the body.

Indexed as

EchinococcosisSubcutaneous TissueAbdominal WallAdultAlbendazoleAnthelminticsFemaleForeheadHumansMaleMiddle AgedAlbendazoleAnthelmintics

Identifiers

PMID40953069
PMCPMC12456795

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.