Evidence map›Paper›PMID 40953033›Full record

ArticlePloS one2025

ZBTB7A regulates CD95-mediated cell growth in colorectal cancer cell lines.

Yanhong Bie, Meiying Bie, Wang Liu, Shufang Tao, Hongyu Xing, Linlin Kuang, Yi Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanhong BieShanghai Jiading District Anting Hospital, Shanghai, China.
Meiying BieShanghai Tianchen Rehabilitation Hospital, Shanghai, China.
Wang LiuShanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.
Shufang TaoShanghai Jiading District Anting Hospital, Shanghai, China.
Hongyu XingShanghai Jiading District Anting Hospital, Shanghai, China.
Linlin KuangShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.ORCID 0009-0004-5752-0063
Yi SongShanghai Jiading Maternal And Child Health Care Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc Finger and BTB Domain-containing7A (ZBTB7A) is a member of the transcription factor family that regulates the expression of numerous genes involved in cell proliferation and differentiation. Ubiquitously expressed in colon, stomach, and other tissues, ZBTB7A performs diverse functions including hematopoiesis, metabolism, and oncogenesis. Here we showed that ZBTB7A knockout inhibited the growth of colon cancer cells and reduced CD95 protein expression by decreasing CD95 mRNA transcription. Overexpression of ZBTB7A could partially restore both CD95 expression and CD95-mediated downstream Caspase2 and JNK2 expression. Furthermore, treatment with ZBTB7A specific inhibitor Curcumin effectively induced colorectal cancer cell death while reducing CD95 expression. These data indicate that ZBTB7A promotes colon cancer cell growth and survival, suggesting its potential as a therapeutic target for colorectal cancer.

Indexed as

Colorectal NeoplasmsDNA-Binding Proteinsfas ReceptorTranscription FactorsApoptosisCell Line, TumorCell ProliferationCurcuminGene Expression Regulation, NeoplasticHumansCurcuminDNA-Binding ProteinsFAS protein, humanfas ReceptorTranscription FactorsZBTB7A protein, human

Identifiers

PMID40953033
PMCPMC12435687

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.